Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dynamic changes of muscle insulin sensitivity after metabolic surgery IV

ABSTRACT: Dynamic changes of muscle insulin sensitivity after metabolic surgery IV

PROVIDER: PRJNA557249 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Dynamic changes of muscle insulin sensitivity after metabolic surgery IV

Project description:The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respiratory control ratio. Persistent elevation of intramyocellular lipid intermediates, likely resulting from unrestrained adipose tissue lipolysis, accompanies the lack of rapid changes in insulin sensitivity. Simultaneously, alterations in skeletal muscle expression of genes involved in calcium/lipid metabolism and mitochondrial function associate with subsequent distinct DNA methylation patterns at 52 weeks after surgery. Thus, initial unfavorable metabolic changes including insulin resistance of adipose tissue and skeletal muscle precede epigenetic modifications of genes involved in muscle energy metabolism and the long-term improvement of insulin sensitivity.

2019-08-14 | GSE135063 | GEO

Dynamic changes of muscle insulin sensitivity after metabolic surgery III

2019-08-14 | GSE134957 | GEO

Dynamic changes of muscle insulin sensitivity after metabolic surgery II

2019-08-14 | GSE134956 | GEO

Dynamic changes of muscle insulin sensitivity after metabolic surgery I

2019-08-14 | GSE134913 | GEO

Dynamic changes of muscle insulin sensitivity after metabolic surgery

Project description:Dynamic changes of muscle insulin sensitivity after metabolic surgery

| PRJNA557248 | ENA

Dynamic changes of muscle insulin sensitivity after metabolic surgery II

Project description:Dynamic changes of muscle insulin sensitivity after metabolic surgery II

| PRJNA557236 | ENA

Dynamic changes of muscle insulin sensitivity after metabolic surgery I

Project description:Dynamic changes of muscle insulin sensitivity after metabolic surgery I

| PRJNA557234 | ENA

Dynamic changes of muscle insulin sensitivity after metabolic surgery III

Project description:Dynamic changes of muscle insulin sensitivity after metabolic surgery III

| PRJNA557237 | ENA

Effects of exercise training on skeletal muscle insulin sensitivity in obesity patients undergoing RYGB surgery: a randomized controlled trial

Project description:We reported that skeletal muscle insulin sensitivity was restored to a lean phenotype with exercise training in patients undergoing RYGB surgery. For that, the goals of this study is to identify changes in the skeletal muscle transcriptome profiling (RNA-seq) that could explain the insulin sensitivity improvement of RYGB + exercise training group.

2020-05-19 | GSE137631 | GEO

Dynamic changes of muscle insulin sensitivity after metabolic surgery

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-08-14 | GSE135066 | GEO