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Sequencing of commercially-available pancreatic cancer cell lines reveals selective CYP3A5 overexpression among xenobiotic-metabolizing CYPs.

ABSTRACT: Sequencing of commercially-available pancreatic cancer cell lines reveals selective CYP3A5 overexpression among xenobiotic-metabolizing CYPs.

PROVIDER: PRJNA575858 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10231339_1.fastq.gz	Fastqsanger.gz
	SRR10231339_2.fastq.gz	Fastqsanger.gz
	SRR10231340_1.fastq.gz	Fastqsanger.gz
	SRR10231340_2.fastq.gz	Fastqsanger.gz
	SRR10231341_1.fastq.gz	Fastqsanger.gz

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Sequencing of commercially-available pancreatic cancer cell lines reveals selective CYP3A5 overexpression among xenobiotic-metabolizing CYPs.

Project description:Purpose: To know the expression of all cytochrome P450 (CYP) enzymes and related drug metabolizing enzymes in pancreatic cancer models Methods: We obtained expression profiles of 8 commercially-available pancreatic cancer cell lines and one non-cancerous immortalized cell line by RNA-sequencing. The pancreatic cancer cells were compared among themselves and to the non-cancerous control cells. Results: We confirmed reports that CYP3A5 is highly overexpressed in pancreatic cancer models, and additionally report that known xenobiotic-metabolizing CYPs are lowly expressed in comparison.

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