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Identification of microRNAs involved in polycystic ovary syndrome based on High-throughput sequencing [miRNA-seq]

ABSTRACT: Identification of microRNAs involved in polycystic ovary syndrome based on High-throughput sequencing [miRNA-seq]

PROVIDER: PRJNA576435 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10244718_1.fastq.gz	Fastqsanger.gz
	SRR10244718_2.fastq.gz	Fastqsanger.gz
	SRR10244719_1.fastq.gz	Fastqsanger.gz
	SRR10244719_2.fastq.gz	Fastqsanger.gz
	SRR10244720_1.fastq.gz	Fastqsanger.gz

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Identification of microRNAs involved in polycystic ovary syndrome based on High-throughput sequencing [miRNA-seq]

Project description:Aberration in miRNA expression or DNA methylation is a causal factor for numerous pathological conditions including polycystic ovarian syndrome PCOS, a common endocrine disorders and leading cause of infertility. The epigenetic interactions between miRNA and DNA methylation remain unexplored in PCOS. Few studies have reported that the regulation of miRNAs in polycystic ovary syndrome(PCOS). Our study helps to understand the molecular pathogenesis of PCOS in human ovarian granulosa cells from the perspective of post-transcriptional level.

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Project description:Exosomes have recently been shown to play a key role in cell-to-cell communication through delivery of various functional content, including microRNAs (miRNAs). We investigated the potential roles of exosomal miRNA derived intrafollicular cells in polycystic ovary syndrome (PCOS). Using microarray profiling, a total of 492 miRNAs and 220 miRNAs were found in follicular fluid-derived exosomes and serum-derived exosomes, respectively, in PCOS and non-PCOS females. By excluding miRNAs existing in serum-derived exosomes, we found 179 miRNAs which were specifically expressed in follicular fluid-derived exosomes both in PCOS and non-PCOS females. Using microarray profiling, a total of 492 miRNAs and 220 miRNAs were found in follicular fluid-derived exosomes and serum-derived exosomes, respectively, in PCOS and non-PCOS females. By excluding miRNAs existing in serum-derived exosomes, we found 179 miRNAs which were specifically expressed in follicular fluid-derived exosomes both in PCOS and non-PCOS females.

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