Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential contribution of p300 and CBP to regulatory elements in mESCs [RNA-seq]

ABSTRACT: Differential contribution of p300 and CBP to regulatory elements in mESCs [RNA-seq]

PROVIDER: PRJNA577737 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10289825_1.fastq.gz	Fastqsanger.gz
	SRR10289825_2.fastq.gz	Fastqsanger.gz
	SRR10289826_1.fastq.gz	Fastqsanger.gz
	SRR10289826_2.fastq.gz	Fastqsanger.gz
	SRR10289827_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Differential contribution of p300 and CBP to regulatory elements in mESCs

Project description:Differential contribution of p300 and CBP to regulatory elements in mESCs

| PRJNA577734 | ENA

Differential contribution of p300 and CBP to regulatory elements in mESCs

Project description:In this study we analyze the individual contribution of p300 and CBP to the H3K27ac landscape, chromatin accessibility, and transcription in mESC. This SuperSeries is composed of the SubSeries listed below.

2020-07-16 | GSE138925 | GEO

Differential contribution of p300 and CBP to regulatory elements in mESCs [ChIP-seq]

Project description:Differential contribution of p300 and CBP to regulatory elements in mESCs [ChIP-seq]

| PRJNA577735 | ENA

Differential contribution of p300 and CBP to regulatory elements in mESCs [ATAC-seq]

Project description:Differential contribution of p300 and CBP to regulatory elements in mESCs [ATAC-seq]

| PRJNA577736 | ENA

Differential contribution of p300 and CBP to regulatory elements in mESCs [RNA-seq]

Project description:In this study we analyze the individual contribution of p300 and CBP to the H3K27ac landscape, chromatin accessibility, and transcription in mESC.

2020-07-16 | GSE138924 | GEO

Differential contribution of p300 and CBP to regulatory elements in mESCs [ATAC-seq]

Project description:In this study we analyze the individual contribution of p300 and CBP to the H3K27ac landscape, chromatin accessibility, and transcription in mESC.

2020-07-16 | GSE138923 | GEO

Differential contribution of p300 and CBP to regulatory elements in mESCs [ChIP-seq]

Project description:In this study we analyze the individual contribution of p300 and CBP to the H3K27ac landscape, chromatin accessibility, and transcription in mESC.

2020-07-16 | GSE138922 | GEO

CBP/p300 transcriptome

Project description:CBP/p300 transcriptome

| PRJNA358160 | ENA

P300-CBP

Project description:Drug target P300/CBP in mCRPC

| PRJEB41497 | ENA

Epigenetic mechanisms to propagate histone acetylation by p300/CBP

Project description:Histone acetylation is important for the activation of gene transcription but little is known about its direct ‘read/write’ mechanisms. Here, we report cryo-electron microscopy structures in which a p300/CBP multidomain monomer recognizes histone H4 N-terminal tail (NT) acetylation (ac) in a nucleosome and acetylates non-H4 histone NTs within the same nucleosome. p300/CBP not only recognized H4NTac via the bromodomain pocket responsible for ‘reading’, but also interacted with the DNA minor grooves via the outside of that pocket. This directed the catalytic center of p300/CBP to one of the non-H4 histone NTs. The primary target that p300 ‘writes’ by ‘reading’ H4NTac was H2BNT, and H2BNTac promoted H2A-H2B dissociation from the nucleosome. We propose a model in which p300/CBP ‘replicates’ histone NT acetylation within the H3-H4 tetramer to inherit epigenetic storage, and ‘transcribes’ it from the H3-H4 tetramer to the H2B-H2A dimers to activate context-dependent gene transcription through local nucleosome destabilization.

2023-05-08 | PXD040835 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data