Ontology highlight
ABSTRACT:
PROVIDER: PRJNA587518 | ENA |
REPOSITORIES: ENA
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Project description:The abundance of transposable elements and DNA repeat sequences in mammalian genomes raises the question whether such insertions represent passive evolutionary baggage or may influence the expression of complex traits. We addressed this question in Drosophila melanogaster where the effects of single transposable elements on complex traits can be assessed in genetically identical individuals reared in controlled environments. Here we demonstrate that single P-element insertions in the intergenic region between the Gustatory receptor 5a (Gr5a) and Trapped in endoderm 1 (Tre1), which encodes an orphan receptor, exert complex pleiotropic effects on fitness traits, including selective nutrient intake, resistance to starvation and heat stress, and life span. Mutations in this region interact epistatically with downstream components of the insulin signaling pathway. Transposon-induced sex-specific and sex-antagonistic effects further accentuate the complex influences intergenic transposable elements can contribute to complex phenotypes. Keywords: Transcriptional profiles of P-element insertion lines in the Tre1/GR5a region of Drosophila
2006-05-31 | GSE4789 | GEO
Project description:A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle
| PRJEB11965 | ENA
Project description:A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle
| PRJEB11963 | ENA