Dataset Information

Hippocampal Gene Expression in bred High Responder (bHR) vs. bred Low Responder (bLR) Rats

ABSTRACT: Hippocampal Gene Expression in bred High Responder (bHR) vs. bred Low Responder (bLR) Rats

PROVIDER: PRJNA590224 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10487019_1.fastq.gz	Fastqsanger.gz
	SRR10487019_2.fastq.gz	Fastqsanger.gz
	SRR10487020_1.fastq.gz	Fastqsanger.gz
	SRR10487020_2.fastq.gz	Fastqsanger.gz
	SRR10487021_1.fastq.gz	Fastqsanger.gz

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Project description:The strong pattern of comorbidity amongst psychiatric disorders is believed to be generated by a spectrum of latent liability, arising from a complex interplay of genetic risk and environmental factors, such as stress and childhood adversity. At one end of this spectrum are internalizing disorders, which are associated with neuroticism, anxiety, and depression. At the other end of the spectrum are externalizing disorders, which are associated with risk-taking and novelty-seeking, as seen in mania, substance abuse, and impulse-control disorders. We model the genetic contributions underlying both extremes of this spectrum by selectively breeding rats that react differently to a novel environment. “Bred high responder” (bHR) rats are highly exploratory with a disinhibited, novelty-seeking temperament, including hyperactivity, aggression, and drug-seeking. “Bred low responder” (bLR) rats are highly-inhibited, exhibiting reduced locomotor activity and anxious and depressive-like behavior. These behavioral propensities are robust and stable, beginning early in development similar to temperament in humans. This dataset was part of a larger RNA-Sequencing study examining gene expression in the bHR/bLR hippocampus, a region critical for emotional regulation. The original study compared repeated injections of either antidepressant medication (fluoxetine or desipramine) or vehicle (VEH=1:1 saline and water) solution in bHR and bLR rats (14 days of intraperitoneal injections - P78-P92, 1 per day) under either standard laboratory housing conditions or chronic variable stress. This upload includes only the data from the control subjects: generation F43 adult male bHR VEH rats and bLR VEH rats housed in standard conditions (n=5/group). Prior to sacrifice, at age P92, the rats underwent social interaction testing after 15 minutes of exposure to an anxiogenic environment (the elevated plus maze). The results from the social interaction testing are provided here along with the gene expression data.

Dataset Information

Hippocampal Gene Expression in bred High Responder (bHR) vs. bred Low Responder (bLR) Rats

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