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Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis [blood array]

ABSTRACT: Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis [blood array]

PROVIDER: PRJNA591703 | ENA |

REPOSITORIES: ENA

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Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis [lung array]

Project description:Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis [lung array]

| PRJNA591702 | ENA

Mouse transcriptome reveals novel signatures of protection and pathogenesis in human tuberculosis [blood]

Project description:Mouse transcriptome reveals novel signatures of protection and pathogenesis in human tuberculosis [blood]

| PRJNA564534 | ENA

Mouse transcriptome reveals signatures of protection and pathogenesis in human tuberculosis

Project description:Mouse transcriptome reveals signatures of protection and pathogenesis in human tuberculosis

| PRJNA591578 | ENA

Mouse transcriptome reveals novel signatures of protection and pathogenesis in human tuberculosis [lung]

Project description:Mouse transcriptome reveals novel signatures of protection and pathogenesis in human tuberculosis [lung]

| PRJNA564540 | ENA

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis [blood array]

Project description:Characterisation of blood and lung global transcriptional responses to Mycobacterium tuberculosis infection in distinct mouse models of Tuberculosis

2020-01-09 | GSE140943 | GEO

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis [lung array]

Project description:Characterisation of blood and lung global transcriptional responses to Mycobacterium tuberculosis infection in distinct mouse models of Tuberculosis

2020-01-09 | GSE140944 | GEO

Antigen-stimulated PBMC transcriptional signatures of protection upon malaria sporozoite and RTS,S/AS01E immunizations

Project description:Identifying immune correlates of protection and mechanisms of immunity accelerates and streamlines the development of vaccines. RTS,S/AS01E, the most advanced malaria vaccine, has moderate efficacy in African children. In contrast, immunization with sporozoites under antimalarial chemoprophylaxis (CPS immunization) can provide 100% sterile protection in naïve adults. We used systems biology approaches to identify correlates of vaccine-induced immunity based on transcriptomes of peripheral blood mononuclear cells from subjects immunized with RTS,S/AS01E or chemo-attenuated sporozoites stimulated with parasite antigens in vitro. Specifically, we used samples of subjects from two age cohorts and 3 African countries participating in an RTS,S/AS01E pediatric phase 3 trial and malaria-naïve subjects participating in a CPS trial. We identified both pre-immunization and post-immunization transcriptomic signatures correlating with protection. Signatures were validated in independent children and infants from the RTS,S/AS01E phase 3 trial and subjects from an independent CPS trial with high accuracies (>70%). Transcription modules revealed interferon, NF-B, TLR, and monocyte-related signatures associated with protection. Pre-immunization signatures suggest the potential for strategies to prime the immune system before vaccination towards improving vaccine immunogenicity and efficacy. Finally, signatures of protection could be useful to determine efficacy in clinical trials, accelerating vaccine candidate testing. Nevertheless, signatures should be tested more extensively across multiple cohorts and trials to demonstrate their universal predictive capacity.

2020-05-13 | GSE144826 | GEO

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis.

Project description:Although mouse infection models have been extensively used to study the host response to Mycobacterium tuberculosis, their validity in revealing determinants of human tuberculosis (TB) resistance and disease progression has been heavily debated. Here, we show that the modular transcriptional signature in the blood of susceptible mice infected with a clinical isolate of M. tuberculosis resembles that of active human TB disease, with dominance of a type I interferon response and neutrophil activation and recruitment, together with a loss in B lymphocyte, natural killer and T cell effector responses. In addition, resistant but not susceptible strains of mice show increased lung B cell, natural killer and T cell effector responses in the lung upon infection. Notably, the blood signature of active disease shared by mice and humans is also evident in latent TB progressors before diagnosis, suggesting that these responses both predict and contribute to the pathogenesis of progressive M. tuberculosis infection.

| S-EPMC7116040 | biostudies-literature

Nos3-/- iPSCs model concordant signatures of in utero cardiac pathogenesis

Project description:Nos3-/- iPSCs model concordant signatures of in utero cardiac pathogenesis

| PRJNA285157 | ENA

Mouse transcriptome reveals novel signatures of protection and pathogenesis in human tuberculosis [blood]

Project description:Characterisation of blood and lung global transcriptional responses to Mycobacterium tuberculosis infection in distinct mouse models of Tuberculosis

2020-01-09 | GSE137092 | GEO

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