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Gene regulation by gonadal hormone receptors defines brain sex differences-[CUT&RUN]

ABSTRACT: Gene regulation by gonadal hormone receptors defines brain sex differences-[CUT&RUN]

PROVIDER: PRJNA604630 | ENA |

REPOSITORIES: ENA

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Gene regulation by gonadal hormone receptors defines brain sex differences-[CUT&RUN]

Project description:Estradiol establishes neural sex differences in many vertebrates and modulates mood, behavior, and energy balance in adulthood. In the canonical pathway, estradiol exerts its effects through the transcription factor estrogen receptor α (ERα). While ERα has been extensively characterized in breast cancer, the neuronal targets of ERα, and their involvement in brain sex differences, remain largely unknown. Here we generate a comprehensive map of genomic ERα-binding sites within a sexually dimorphic neural circuit that mediates social behaviors. We conclude that ERα orchestrates sexual differentiation of the mouse brain through two mechanisms: establishing two male-biased neuron types and activating a sustained male-biased gene expression program. Collectively, our findings reveal that sex differences in gene expression are defined by hormonal activation of neuronal steroid receptors. The molecular targets we identify may underlie the effects of estradiol on brain development, behavior, and disease.

2022-04-20 | GSE144716 | GEO

Gene regulation by gonadal hormone receptors defines brain sex differences

Project description:Gene regulation by gonadal hormone receptors defines brain sex differences

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Bulk Cut&run and Cut&tag

Project description:Bulk Cut&run and Cut&tag

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Gene regulation by gonadal hormone receptors defines brain sex differences-[ATAC-Seq]

Project description:Gene regulation by gonadal hormone receptors defines brain sex differences-[ATAC-Seq]

| PRJNA604615 | ENA

Gene regulation by gonadal hormone receptors defines brain sex differences-[Multiome-Seq]

Project description:Gene regulation by gonadal hormone receptors defines brain sex differences-[Multiome-Seq]

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Gene regulation by gonadal hormone receptors defines brain sex differences-[snRNA-Seq]

Project description:Gene regulation by gonadal hormone receptors defines brain sex differences-[snRNA-Seq]

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Gene regulation by gonadal hormone receptors defines brain sex differences-[RNA-Seq]

Project description:Gene regulation by gonadal hormone receptors defines brain sex differences-[RNA-Seq]

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CUT&RUN HUDEP1 OE SOX6-Flag

Project description:SOX6 CUT&RUN on HUDEP1 over expressing SOX6-Flag. The experiment is done using and anti Flag Ab to assist the genome wide binding profile of SOX6 in HUDEP1 (Human Umbilical cord blood-Derived Erythroid Progenitor-1).

2023-04-07 | E-MTAB-12800 | biostudies-arrayexpress

Identification of chromatin states during zebrafish gastrulation using CUT&RUN and CUT&Tag

Project description:Here we describe successful implementation of CUT&RUN for profiling protein-DNA interactions in zebrafish embryos. We apply modified a CUT&RUN method to generate high resolution maps of enrichment for H3K4me3, H3K27me3, H3K9me3, and RNA polymerase II during zebrafish gastrulation. Using this data, we identify a conserved subset of developmental genes that are enriched in both H3K4me3 and H3K27me3 during gastrulation, and we demonstrate the increased effectiveness of CUT&RUN for detecting protein enrichment at repetitive sequences with reduced mappability. Our work demonstrates the power of combining CUT&RUN with the strengths of the zebrafish system to better understand the changing embryonic chromatin landscape and its roles in shaping development.

2021-06-17 | GSE178343 | GEO

Gene regulation by gonadal hormone receptors defines brain sex differences-[snRNA-Seq]

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