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Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease [bulk RNA]

ABSTRACT: Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease [bulk RNA]

PROVIDER: PRJNA607214 | ENA |

REPOSITORIES: ENA

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Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

Project description:Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

| PRJNA607212 | ENA

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease [bulk RNA]

Project description:Obstructive sleep apnea (OSA) results from episodes of airway collapse and intermittent hypoxia (IH) and is associated with a host of health complications. Although the lung is the first organ to sense changes in oxygen levels, little is known about the consequences of IH to the lung hypoxia-inducible factor- (HIF)-responsive pathways. We hypothesized that exposure to IH would lead to cell-specific up and downregulation of diverse expression pathways. We identified changes in circadian and immune pathways in lungs from mice exposed to IH. Among all cell types, endothelial cells showed the most prominent transcriptional changes. Upregulated genes in myofibroblast cells were enriched for genes associated with pulmonary hypertension and included targets of several drugs currently used to treat chronic pulmonary diseases. A better understanding of the pathophysiologic mechanisms underlying diseases associated with OSA could improve our therapeutic approaches, directing therapies to the most relevant cells and molecular pathways.

2021-02-18 | GSE145434 | GEO

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease [single-cell RNA]

Project description:Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease [single-cell RNA]

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Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease [single-cell RNA]

2021-02-18 | GSE145435 | GEO

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease.

Project description:Obstructive sleep apnea (OSA) results from episodes of airway collapse and intermittent hypoxia (IH) and is associated with a host of health complications. Although the lung is the first organ to sense changes in oxygen levels, little is known about the consequences of IH to the lung hypoxia-inducible factor-responsive pathways. We hypothesized that exposure to IH would lead to cell-specific up- and downregulation of diverse expression pathways. We identified changes in circadian and immune pathways in lungs from mice exposed to IH. Among all cell types, endothelial cells showed the most prominent transcriptional changes. Upregulated genes in myofibroblast cells were enriched for genes associated with pulmonary hypertension and included targets of several drugs currently used to treat chronic pulmonary diseases. A better understanding of the pathophysiologic mechanisms underlying diseases associated with OSA could improve our therapeutic approaches, directing therapies to the most relevant cells and molecular pathways.

| S-EPMC7909952 | biostudies-literature

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-02-18 | GSE145436 | GEO

Intermittent Hypoxia ageing

Project description:Expression data from mice exposed to intermittent hypoxia and mice reared for 12 months. We used microarrays to analyze the transcriptome of hippocampus from mice exposed to intermittent hypoxia or aged mice.

2016-12-27 | GSE62385 | GEO

GNPS_2017 Mouse intermittent hypoxia (IH) - Aorta & pulmonary artery

Project description:2017 Mouse intermittent hypoxia (IH) - Aorta & pulmonary artery Contains LC/MS data for 10-week experiments involving mice raised in environments with normal oxygen, intermittent hypoxia (IH).

2019-02-25 | MSV000083483 | GNPS

Neonatal intermittent hypoxia exposure sex-specifically augments rat microglial cytokine expression acutely and long-term

Project description:We analyzed gene expression via RNA-sequencing in microglia isolated from postnatal day 9 rats exposed to normoxia or intermittent hypoxia, in the presence or absence of lipopolysaccharide

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Temporal effects of intermittent- and sustained hypoxia on gene expression patterns in rat lungs

Project description:Time-course gene expression profiles were obtained from lung tissues of the rats treated with room air, intermittent- (IH) or sustained hypoxia (SH) for 1, 3, 7, 14 and 30 days using CodeLink microarrays. Using a systems biology approach, we observed that two different mechanisms are involved in the lung responses to IH and SH: IH leads to increased G-protein coupled signaling-, ion transport-, neuronal- and steroid hormone receptor activities; whereas SH causes increased blood vessel morphogenesis and immune responses. Our results provide insight into molecular mechanisms underlying IH and SH. Keywords: gene expression array-based, count rats were treated with intermittent- (IH) or sustained hypoxia (SH) for 1, 3, 7, 14 and 30 days; rats treated with room air were used as controls; gene expression profiles were obtained from these rats

2008-12-17 | E-GEOD-8705 | biostudies-arrayexpress

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