Project description:To better understand the critical drivers of Zika virus pathogenicity, we used microarray analysis to evaluate the host responses triggered by Zika virus infection in MRC-5 cells.
Project description:Primary human monocytes were isolated and differentiated into moDCs. These moDCs were infected with different Zika virus (ZIKV) strains (namely DN-1, DN-2 and H/PF/2013) and YF17D (as compared to non-infected controls, \\"mock\\") to better understand the gene expression changes induced by these different viruses. moDCs were harvested at 24 hours post-infection and microarray performed with the Affymetrix GeneChip Human Gene 2.0 ST Array.
Project description:We repoted the Glioblastoma stem cells(GSCs) infected by two strains of ZIKA virus, the Brazil and Dakar strains. The ZIKV was added into the medium of GSCs for 48 hours, the RNA was harvested after ZIKV infection. We found that the GSCs up-regulated the Type 1&2 interferons after infected by ZIKV
