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Tcf1 and Lef1 regulate follicular helper T cell function eliciated by vaccination

ABSTRACT: Tcf1 and Lef1 regulate follicular helper T cell function eliciated by vaccination

PROVIDER: PRJNA610563 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11244246_1.fastq.gz	Fastqsanger.gz
	SRR11244246_2.fastq.gz	Fastqsanger.gz
	SRR11244247_1.fastq.gz	Fastqsanger.gz
	SRR11244247_2.fastq.gz	Fastqsanger.gz
	SRR11244248_1.fastq.gz	Fastqsanger.gz

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Tcf1 and Lef1 regulate follicular helper T cell function eliciated by vaccination [ATAC-Seq]

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Project description:Comparison of epigenome and Tcf1 occupancy between control and Tcf1/Lef1-deficient CD8 T cells Control mice or those are deficient for Tcf1 and Lef1 transcription factors (deleted by CD4-Cre) were used to isolate thymocytes. The thymocytes were surface-stained to identify TCRbeta high, CD69â, CD24â CD8+ subsets. These cells were sorted for ChIPseq analysis of various histone marks. Control mice or those are deficient for Tcf1 (deleted by CD4-Cre) were used to isolate thymocytes. The splenocytes were surface-stained to identify TCRbeta high, CD8+ subsets. These cells were sorted for ChIPseq analysis of Tcf1 binding locations.

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