Project description:Imaging run on co-culture and isolated cultures of Penicillium sp. #12 with Glutamicibacter arilaitensis. Both strains were isolated from cheese rinds and normalized to OD 0.1 before plating on 2.5% Cheese Curd agar and grown for 7 days at room temperature.
Project description:Imaging run on co-culture and isolated cultures of Penicillium sp. #12 with Glutamicibacter arilaitensis. Both strains were isolated from cheese rinds and normalized to OD 0.1 before plating on 2.5% Cheese Curd agar that was normalized to a pH of 5 and grown for 7 days at room temperature.
Project description:As part of our investigations on the chemical diversity of organisms from unexplored marine habitats of Mexico, a series of 29 fungal strains isolated from deep-sea sediments (more than 600 m deep) from the Gulf of Mexico were investigated. The antimicrobial potential of their organic extracts from solid cultures grown under the OSMAC approach was assessed against a panel of ESKAPE bacteria and the yeast C. albicans. Chemical studies on the active scaled-up cultures and some small-scale cultures led to the isolation of benzochromenones from Alternaria sp. CIGOM4, benzodiazepines from P. echinulatum CONTIG4, a cytochalsin from Biatriospora sp. CIGOM2, and an imidazopyridoindole from Penicillium sp. CIGOM10. Molecular network analysis by GNPS combined with manual dereplication showed the enormous potential of these fungi to produce bioactive compounds.
Project description:In Aspergillus sp., BrlA is a master transcription factor essential for the induction of conidiogenesis. Sometimes it is also involved in the secondary metabolism. The aim of this study was to characterize the role of BrlA in Penicillium expansum. For that a null mutant PeΔBrlA was generated.
