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Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production.

ABSTRACT: Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production.

PROVIDER: PRJNA613488 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11353921.fastq.gz	Fastqsanger.gz
	SRR11353922.fastq.gz	Fastqsanger.gz
	SRR11353923.fastq.gz	Fastqsanger.gz
	SRR11353924.fastq.gz	Fastqsanger.gz
	SRR11353925.fastq.gz	Fastqsanger.gz

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Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production.

Project description:Acute liver failure is a clinical syndrome of severe hepatic dysfunction. Immune cells play an important role in the failure. In recent years, the immunoregulatory function of extracellular vesicles (EVs) has been reported; therefore, it is inferred that EVs have some role in an immune mediated liver injury. In this study, we investigated the immunoregulatory function of EVs in a concanavalin A (Con A)-induced liver injury. The mouse model was prepared by a single intravenous administration of 15 mg/kg Con A, in which there was a significant increase in serum EVs number. In in vitro study, the secreted EVs number was also significantly increased in Con A-treated RAW264.7, a mouse macrophage cell line, but not Hepa1-6, a mouse hepatoma cell line. In in vitro EVs treatment study, the EVs from Con A-treated mice serum and Con A-treated RAW264.7 suppressed the inflammatory cytokines production in Con A-stimulated RAW264.7. miRNA sequencing analysis showed that mmu-miR-122-5p and mmu-miR-148a-3p were commonly increased in these EVs and the EVs-treated cells. The enriched pathways in the miRNAs predicted target genes included the inflammatory response pathways. mRNA levels of the target genes in the pathways (mitogen-activated protein kinase, Phosphoinositide 3-kinase/Akt and Rho/Rho associated coiled-coil containing protein kinase pathways) were decreased in the EVs-treated cells. In in vivo RNA interference study, knock down of liver RAB27A, an EVs secretion regulator, significantly exacerbated the Con A-induced liver injury. These data suggest that macrophage-derived EVs play an important role in a Con A-induced liver injury through the immunoregulation.

2020-03-20 | GSE147243 | GEO

Effect of YTHDF1 on concanavalin A-induced hepatitis

Project description:To investigate the effect of YTHDF1 on concanavalin A (ConA)-induced hepatitis , we performed RNA-seq with the total RNA extracted from the moue liver. Ythdf1-/- or wild type mice were intravenously injected with ConA (8 mg/kg) or saline for 8 hours. Then, the livers were collected, homogenized, and subjected to total RNA extraction.

2023-08-08 | GSE238229 | GEO

Effect of a DP1 agonist BW245C on concanavalin A-induced hepatitis

Project description:To elucidate the effect of a prostaglandin D2 receptor DP1 agonist BW245C on concanavalin A (ConA) hepatitis, we performed DNA microarray using SurePrint G3 Mouse GE 8x60K Microarray. Mice were treated with ConA for 3 or 24 hr with vehicle or BW245C . Livers were collected, homogenized, and subjected to total RNA extraction.

2015-06-01 | GSE45413 | GEO

Human Wharton's jelly-derived mesenchymal stem cells alleviate Concanavalin A-induced fulminant hepatitis by repressing NF-κB signaling and glycolysis

Project description:RNA sequencing of mouse liver tissues 24 hours after Concanavalin A (Con A) administration.

2021-08-31 | GSE182182 | GEO

Role of Hif1alpha in cytokine-induced macrophage gene expression

Project description:Role of Hif1alpha in cytokine-induced macrophage gene expression

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CECR2 Drives Breast Cancer Metastasis by Suppressing Macrophage Inflammatory Responses

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Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production of Th2 Cells

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RNA-sequence facilitates analysis of mesenchymal stem cells treating with concanavalin A mice

Project description:Purpose: The goals of this study are to find the mechanisms of mesenchymal stem cells (MSC) ameliorating concanavalin A (Con A) induced inflammatory mice Methods: Liver tissues were harvested at 6h, 12h after Con A injected with/without MSC (n = 3 per group) for transcriptome profiling. Results: Filter the raw data obtained fromDNBSEQ-G400, and compare the filtered clean reads to the reference sequence. Quantitative analysis of known genes and new genes, differential expression analysis based on gene expression in different sample groups, GO function analysis, Pathway function analysis, cluster analysis, and protein interaction for the selected differentially expressed genes Network, transcription factor coding ability prediction and other in-depth mining analysis. Conclusions: Our study discoveres following processes were significantly affected: apoptosis, MAPK signaling pathway and cytokine-cytokine receptor interaction.

2023-07-01 | GSE178696 | GEO

H3K27me3 regulates macrophage cytokine transcription and impacts on Collagen Induced Arthritis

Project description:H3K27me3 regulates macrophage cytokine transcription and impacts on Collagen Induced Arthritis

| PRJNA779693 | ENA

stem cell therapy of murine acute hepatitis

Project description:Gene expression profiles of the liver and hepatic inflammatory cells in murine concanavalin A-induced acute hepatitis models by treatment with adipose tissue derived stem cells C57Bl/6 female mice were treated with adipose tissue-derived stem cells immediately or 3 hours after concanavalin A injection. Two hours later, the liver tissues or hepatic inflammatory cells were obtained and gene expression of them were examined by DNA microarray.

2012-10-11 | E-GEOD-41465 | biostudies-arrayexpress

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