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Breastmilk

ABSTRACT: Breastmilk Metagenome

PROVIDER: PRJNA613840 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11363700.fastq.gz	Fastqsanger.gz
	SRR11363800.fastq.gz	Fastqsanger.gz
	SRR11363701.fastq.gz	Fastqsanger.gz
	SRR11363801.fastq.gz	Fastqsanger.gz
	SRR11363702.fastq.gz	Fastqsanger.gz

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Human breastmilk memory T cells throughout lactation manifest an activated and tissue-oriented profile with prominent regulation

Project description:Breastfeeding provides important immunological benefits to the neonate, but how different immunoactive components in breastmilk contribute to immunity remains poorly understood. Here, we characterized human breastmilk T cells using single cell RNA sequencing and flow cytometry. Breastmilk contained predominantly memory T cells with immune response signaling, proliferation and an effector Th1/cytotoxic profile with high cytokine production capacities. High activation markers were balanced by an enriched Treg population and immune regulatory markers in conventional memory T cells. Gene and surface expression of tissue-residency markers indicated that breastmilk T cells represent tissue-adapted rather than circulatory T cells. In addition, breastmilk T cells had a broad homing profile and higher activation markers in these migratory subsets. The partly overlapping transcriptome profile between breastmilk and breast tissue T cells, particularly cytotoxic T cells, might support a role in local immune defense in the mammary gland. However, unique features of breastmilk, such as regulatory T cells, might imply an additional role in neonatal immune defense. We found some correlations between the breastmilk T-cell profile and clinical parameters, most notably with maternal and household factors. . Together, our data suggest that breastmilk contains an adapted T cell population that exerts their function in specific tissue-sites.

2024-07-26 | GSE273105 | GEO

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The Campylobacter jejuni cell membrane protects against the bactericidal activity of human breastmilk

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Breastmilk proteomics dataset of puerperant women with COVID-19

Project description:Quantitative proteomic analysis was performed to demonstrate the changes of bioactive components in breastmilk of puerperant women with COVID-19.

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Project description:The nutrition contents of breastmilk can transfer into the blood of neonates, directly participating in neonatal immune response. The alternations of the components of breastmilk under the context of viral infection not only reflect the physiological changes in mothers but also affect neonatal immunity and metabolism via breastfeeding. There has been no report to demonstrate the changes of bioactive components in breastmilk of puerperant women with COVID-19. Thereby, we attempted to answer the important questions whether breastmilk production is affected by COVID-19 and whether breastfeeding is still a safe or recommended operation for puerperant women with COVID-19.

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Small RNA sequencing of human milk cells reveals numerous known and novel miRNAs, with no effects of milk removal

Project description:Very little is known about miRNAs found in breastmilk cells, which also reflect the cells of the lactating mammary epithelium. Our hypothesis is that breastmilk cells are richer in miRNA compared to other milk fractions, such as skim milk. Further, the effects of milk removal by the infant on milk cell miRNA content and/or composition have not been investigated. Breastmilk cells conserved higher miRNA content than previously published lipid and skim fractions of breastmilk as well as other known sources of miRNA in humans. Specifically, 1,467 known mature miRNAs were identified and a further 1996 novel miRNAs, of which 89 were highly expressed. As previously shown, post-feed milk contained more cells than pre-feed milk, and the same was observed for miRNA content. However, no statistically significant difference was found in the expression of the total known and novel miRNAs between pre- and post-feed milk (p=0.76), although 27 known miRNAs and 1 novel miRNA were higher expressed in post-feed milk. As expected, samples richer in viable cells contained more known miRNAs (p = 0.01). Functional analysis of the top 10 most highly expressed known miRNAs showed that they may be potentially involved in crucial roles for the infant, including body fluid balance, thirst, appetite, immune responses, and development. In conclusion, breastmilk is highly rich in miRNA which may play important functions in the breastfed infant and the lactating breast. Milk removal by the infant can influence the total miRNA content of breastmilk, similar to its cell and fat content, but the miRNA composition remains constant

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