Project description:Background: Parasitic helminths influence the composition of the gut microbiome. However, the microbiomes of individuals living in helminth-endemic regions are understudied. The Orang Asli, an indigenous population in Malaysia with high burdens of the helminth Trichuris trichiura, display microbiotas enriched in Clostridiales, an order of spore-forming obligate anaerobes with immunogenic properties. We previously isolated novel Clostridiales that were enriched in these individuals and found that a subset promoted the Trichuris life cycle. In this study, we aimed to further characterize the functional properties of these bacteria.Results: Clostridiales isolates were profiled for their ability to perform 57 enzymatic reactions and produce short chain fatty acids (SCFAs) and hydrogen sulfide, revealing that these bacteria were capable of a range of activities associated with metabolism and host response. Consistent with this finding, monocolonization of mice with individual isolates identified bacteria that were potent inducers of regulatory T cell (Treg) differentiation in the colon. Comparisons between variables revealed by these studies identified enzymatic properties correlated with Treg induction and Trichuris egg hatching.

2024-05-17 | GSE262316 | GEO

Clostridiaceae bacterium JC118

Project description:Clostridiaceae bacterium JC118 overview

| PRJNA81053 | ENA

Clostridia bacterium

Project description:Clostridia bacterium overview

| PRJNA700747 | ENA

Clostridiaceae bacterium 14S0207

Project description:Clostridiaceae bacterium 14S0207 Genome sequencing

| PRJNA432648 | ENA

Clostridiaceae bacterium JC118

Project description:Clostridiaceae bacterium JC118 Genome sequencing

| PRJEA70545 | ENA

Effect of Clostridia strains on EAE clinical outcome as a therapeutic treatment

Project description:Researchers have induced an experimental model of multiple sclerosis [experimental autoimmune encephalomyelitis (EAE)] in mice to investigate the therapeutic effect of the oral treatment with selected Clostridia strains on the clinical outcome of EAE and its mechanisms of action

2021-09-15 | GSE155438 | GEO

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