Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

To study the function of KLF5 in squamous cancers and gastrointestinal cancers [HiChIP]

ABSTRACT: To study the function of KLF5 in squamous cancers and gastrointestinal cancers [HiChIP]

PROVIDER: PRJNA622287 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11459775_1.fastq.gz	Fastqsanger.gz
	SRR11459775_2.fastq.gz	Fastqsanger.gz
	SRR11459776_1.fastq.gz	Fastqsanger.gz
	SRR11459776_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

To study the function of KLF5 in squamous cancers and gastrointestinal cancers [HiChIP]

Project description:To identify KLF5 target genes by integrating ChIP-seq, HiChIP and RNA-seq assays

2020-12-09 | GSE147854 | GEO

To study the function of KLF5 in squamous cancers and gastrointestinal cancers

Project description:To study the function of KLF5 in squamous cancers and gastrointestinal cancers

| PRJNA622284 | ENA

To study the function of KLF5 in squamous cancers and gastrointestinal cancers [RNA-seq]

Project description:To identify KLF5 target genes and study the gene regulation function of KLF5 by integrating ChIP-seq, HiChIP and RNA-seq assays

2020-12-09 | GSE147855 | GEO

To study the function of KLF5 in squamous cancers and gastrointestinal cancers [ChIP-seq]

Project description:To identify KLF5 target genes and study the gene regulation function of KLF5 by integrating ChIP-seq, HiChIP and RNA-seq assays

2020-12-09 | GSE147853 | GEO

To study the function of KLF5 in squamous cancers and gastrointestinal cancers [ChIP-seq]

Project description:To study the function of KLF5 in squamous cancers and gastrointestinal cancers [ChIP-seq]

| PRJNA622288 | ENA

To study the function of KLF5 in squamous cancers and gastrointestinal cancers [RNA-seq]

Project description:To study the function of KLF5 in squamous cancers and gastrointestinal cancers [RNA-seq]

| PRJNA622286 | ENA

Functional characterization of genetic variants associated with upper digestive cancers [HiChIP]

Project description:Using H3K27ac HiChIP assays to link genetic variants to target genes in upper digestive cancers

2024-02-25 | GSE235431 | GEO

To study the function of KLF5 in squamous cancers and gastrointestinal cancers

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-12-09 | GSE147856 | GEO

Cancer gene discovery in mouse gastrointestinal cancers

Project description:Cancer gene discovery in mouse gastrointestinal cancers

| PRJEB2471 | ENA

Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers

Project description:The transcription factor KLF5 is highly expressed in basal-like breast cancer (BLBC). It promotes cell proliferation, survival, migration and stemness and serves as a potential therapeutic target. In this study, we first identified a super-enhancer (SE) located downstream of the KLF5 gene in BLBC. JQ-1, a BRD4-bromodomain inhibitor, inhibits the expression and activity of KLF5 in the HCC1806 and HCC1937 cell lines in time- and dose-dependent manners. A new BRD4 inhibitor, compound 870, is more potent than JQ-1 in terms of its ability to inhibit KLF5 and BLBC growth by inducing G1 phase cell cycle arrest. Additionally, a CDK7 inhibitor, THZ1, also inhibits KLF5 and BLBC growth. Our findings suggested that SE regulates KLF5 and that SE inhibitors could be an effective therapeutic strategy for treating BLBC.

2019-10-01 | GSE124748 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data