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Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation

ABSTRACT: Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation

PROVIDER: PRJNA623885 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11582700_1.fastq.gz	Fastqsanger.gz
	SRR11582700_2.fastq.gz	Fastqsanger.gz
	SRR11582800_1.fastq.gz	Fastqsanger.gz
	SRR11582800_2.fastq.gz	Fastqsanger.gz
	SRR11582900_1.fastq.gz	Fastqsanger.gz

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Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation [III]

Project description:Metastasis is promoted by fatty acid (FA) uptake and metabolism1-2. How this works, or whether all dietary FAs are prometastatic, is not known. Here we show that dietary palmitic acid (PA), but not oleic acid (OA) or linoleic acid, promotes metastasis, indicating specificity of action for distinct FAs. Strikingly, tumours acutely exposed to a PA–rich diet remain highly metastatic even when serially transplanted. This PA–induced prometastatic memory requires the FA transporter CD36 as well as the epigenetically stable deposition of histone H3 lysine 4 trimethylation by the methyltransferase Set1A/COMPASS. Genes with this metastatic memory predominantly relate to a neural signature that stimulates intratumor oligodendrogenesis and perineural invasion, two parameters strongly correlated with metastasis but etiologically poorly understood3-4. Mechanistically, induction of the epigenetic neural signature and its associated long-term boost in metastasis downstream of PA require the transcription factor EGR2 and the oligodendrocyte-stimulating peptide galanin. We provide evidence for a long-term epigenetic stimulation of metastasis by a dietary metabolite related to tumor innervation. In addition to underscoring the potential danger of eating large amounts of PA (and perhaps other saturated fats), our results reveal novel epigenetic and neural-related therapeutic strategies for metastasis.

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Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation [IV]

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Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation [II]

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Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation [I]

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Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation

Project description:Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation

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Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation [III]

Project description:Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation [III]

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Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation [II]

Project description:Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation [II]

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Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation [I]

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Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation [IV]

Project description:Dietary palmitic acid promotes a prometastatic epigenetic memory related to tumor innervation [IV]

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Dietary palmitic acid promotes a prometastatic memory based on Schwann Cell activation

Project description:Metastasis is promoted by fatty acid (FA) uptake and metabolism 1-2 . How this works, or whether all dietary FAs are prometastatic, is not known. Here we show that dietary palmitic acid (PA), but not oleic acid (OA) or linoleic acid, promotes metastasis in oral carcinomas and melanoma, indicating specificity of action for distinct FAs. Strikingly, tumours acutely exposed to a PA–rich diet remain highly metastatic even when serially transplanted. This PA–induced prometastatic memory requires the FA transporter CD36 as well as the epigenetically stable deposition of histone H3 lysine 4 trimethylation by the methyltransferase Set1A/COMPASS. Bulk, single cell and positional RNA sequencing indicate that genes with this metastatic memory predominantly relate to a neural signature that stimulates activation of intratumor Schwann cells and perineural invasion, two parameters strongly correlated with metastasis but etiologically poorly understood 3-4 . Mechanistically, tumour-associated Schwann cells secrete a specialized pro-regenerative extracellular matrix reminiscent of perineuronal nets, which when ablated strongly inhibits metastatic colonization. The induction of the epigenetic neural signature and its associated long-term boost in metastasis downstream of PA require the transcription factor EGR2 and the glial cell-stimulating peptide galanin. We provide evidence for a long-term epigenetic stimulation of metastasis by a dietary metabolite related to a pro-regenerative state of tumour-activated Schwann cells. In addition to underscoring the potential danger of eating large amounts of PA, our results reveal novel epigenetic and neural-related therapeutic strategies for metastasis.

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