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Nanostring analysis of MC38 tumors in PBS and hetIL-15-treated mice

ABSTRACT: Nanostring analysis of MC38 tumors in PBS and hetIL-15-treated mice

PROVIDER: PRJNA631901 | ENA |

REPOSITORIES: ENA

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Nanostring analysis of MC38 tumors in PBS and hetIL-15-treated mice

Project description:Comparison of gene expression identified several significantly overexpressed genes in tumors recovered from hetIL-15-treated mice. These upregulated genes after hetIL-15 treatment represent an expression signature that corresponds to activated TILs with cytotoxic phenotype. Nanostring analysis also identified additional functional pathway signatures, including signal transducer and activator of transcription (STAT) intracellular signaling, TCR recognition of cognate antigen, interferons signaling, increased metabolic rate and immune cell chemotaxis

2020-05-13 | GSE150357 | GEO

RNA-seq of parental MC38 and anti-PD-1 resistant MC38 subcutaneous tumors

Project description:MC38 tumors resistant to anti-PD-1 treatment (MC38-resistant) were generated through serial in vivo passaging, and global gene expression analysis was used to compare resistant and parental tumors. MC38 and MC38-resistant tumors exhibited widespread changes in global gene expression.

2021-07-22 | GSE180309 | GEO

Transcriptomic profiling of MC38 tumor cells on murine MC38 liver metastasis sections by NanoString GeoMX DSP

Project description:To study how targeting Glut1 in CAFs influences the transcritome of adjacent cancer cells, MC38 adjacent to control CAFs and Glut1-deficient CAFs were subjected to spatial transcriptomic profiling with the NanoString GeoMx DSP

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Single-cell RNAseq of CD45 positive cells in MC38 tumors - Primary irradiated tumors and secondary non-irradiated tumors - Concurrent treatment with anti-PD-L1

Project description:Primary irradiated MC38 tumors and secondary MC38 non-irradiated tumors. Subcutaneous MC38 tumors in C57BL/6 mice Concurrent treatment with anti-PD-L1.

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Transcriptomic profiling of the cancer-associated fibroblasts (CAFs) on murine MC38 liver metastasis sections by NanoString GeoMX DSP

Project description:To study how targeting Glut1 influences the transcriptome of cancer-associated fibroblasts (CAFs), the transcriptome of control CAFs and that of Glut1-deficient CAFs on murine MC38 liver metastasis sections were obtained and compared with the NanoString GeoMx DSP

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RNAseq of macrophages and NK cells from MC38 tumors with PtdSer externalization blockade

Project description:The goals of this study are to compare NGS-derived transcriptome profiling (RNA-seq) of tumor associated macrophages from WT MC38 tumors and Tmem30a KO tumors; and NK cells from WT and Xkr8 KO MC38 TILs

2022-06-04 | GSE200752 | GEO

RNAseq of macrophages from MC38 tumors with PtdSer externalization blockade

Project description:The goals of this study are to compare NGS-derived transcriptome profiling (RNA-seq) of tumor associated macrophages from WT MC38 tumors and Xkr8 KO tumors

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RNA-seq of parental MC38 and anti-PD-1 resistant MC38 subcutaneous tumors

Project description:RNA-seq of parental MC38 and anti-PD-1 resistant MC38 subcutaneous tumors

| PRJNA747799 | ENA

Analysis of endothelial cells related gene in MC38 tumors

Project description:We show that endothelial cells from MC38 tumors in WT mice express high chemokine Ccl8 than in Apelin knockout mice. We found that Apelin induces Ccl8 expression in ECs and enhances anti-tumor immunity.

2021-06-23 | GSE178681 | GEO

Single cell TCR-seq of T cells isolated from MC38 mouse tumors

Project description:We investigate the single-cell landscape of the inflammatory mouse tumor model MC38, a C57BL/6 tumor cell line derived from colon adenocarcinoma. MC38 (diluted in HBSS and matrigel) was inoculated in the right unilateral flank (in the border of positions B2 and B3) of C57BL/6 mice (ref Study 16-3384 AV). Tumors were taken one day after group-out (average 150-250 mm3 at day 0), approximately 14-19 days. Tissues were dissociated and flow sorted accordingly to obtain the following groups for 10x Chromium 5' Gene Expression Profiling. Our results indicate that the degree of clonal expansion is correlated with expression of T cell exhaustion markers, and that T cells with strong exhaustion phenotype also express high levels of activation markers, such as interferon gamma.

2019-05-11 | E-MTAB-7918 | biostudies-arrayexpress

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