Project description:The gut microbiota promotes immune system development in early life, but the interactions between the gut metabolome and immune cells in the neonatal gut remains largely undefined. Here, we demonstrate that the neonatal gut is uniquely enriched with neurotransmitters, including serotonin; specific gut bacteria produce serotonin directly while downregulating monoamine oxidase A to limit serotonin breakdown. Serotonin directly signals to T cells to increase intracellular indole-3-acetaldehdye to inhibit mTOR activation and thereby promotes the differentiation of regulatory T cells, both ex vivo and in vivo in the neonatal intestine. Oral gavage of serotonin into neonatal mice leads to long-term T cell-mediated antigen-specific immune tolerance towards both dietary antigens and commensal bacteria. Together, our study has uncovered an important role for unique gut bacteria to increase serotonin availability in the neonatal gut and a novel function of gut serotonin to shape T cell response to dietary antigens and commensal bacteria to promote immune tolerance in early life.

2024-01-31 | GSE248691 | GEO

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells I

2024-01-31 | GSE248690 | GEO

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells III

2024-01-31 | GSE248692 | GEO

Co-infection of fungi and bacteria in brain tissue of Alzheimer’s patients.

Project description:Metagenomics analysis reveals co-infection of fungi and bacteria isolated from different regions of brain tissue from elderly persons and patients with Alzheimer's disease.

| EGAS00001002766 | EGA

Depolymerization of plant cell wall glycans by symbiotic human gut bacteria

Project description:This SuperSeries is composed of the following subset Series: GSE25572: Depolymerization of plant cell wall glycans by symbiotic human gut bacteria (Bacteroides thetaiotaomicron) GSE25575: Depolymerization of plant cell wall glycans by symbiotic human gut bacteria (Bacteroides ovatus) Refer to individual Series

2011-05-01 | E-GEOD-25576 | biostudies-arrayexpress

Bacteria and Fungi

Project description:Bacteria and Fungi Raw sequence reads

| PRJNA355599 | ENA

Bacteria and fungi

Project description:Bacteria and fungi from soil isolates

| PRJNA726977 | ENA