Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression of mouse colon organoids after the removal of inflammatory reagents.

ABSTRACT: Gene expression of mouse colon organoids after the removal of inflammatory reagents.

PROVIDER: PRJNA641673 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Gene expression of mouse colon organoids after the removal of inflammatory reagents.

Project description:Microarray analysis of mouse colon organoids after the removal of inflammatory reagents following long-term treatment with inflammatory reagents.

2020-06-25 | GSE153175 | GEO

Mouse colon organoids treated with inflammatory reagents.

Project description:Mouse colon organoids treated with inflammatory reagents.

| PRJNA641669 | ENA

Gene expression of mouse colon organoids treated with inflammatory reagents.

Project description:Microarray analysis of mouse colon organoids after treatment with the mixture of inflammatory reagents.

2020-06-25 | GSE153176 | GEO

Gene expression of mouse colon organoids treated with inflammatory reagents.

Project description:Gene expression of mouse colon organoids treated with inflammatory reagents.

| PRJNA641674 | ENA

Red Algae-Derived Mineral Intervention to Counter Pro-inflammatory Activity in Human Colon Organoids

Project description:Human colon organoids were maintained in culture medium alone or exposed to lipopolysaccharide with a combination of three pro-inflammatory cytokines (tumor necrosis factor-a, interleukin-1b and interferon-g [LPS-cytokines]) to mimic the environment in the inflamed colon. Untreated organoids and those exposed to LPS-cytokines were concomitantly treated with a multi-mineral product that has previously been shown to improve barrier structure/function. The organoids were subjected to proteomic analysis to obtain a broad view of the protein changes induced by these interventions. In parallel, confocal fluorescence microscopy and trans-epithelial electrical resistance measurements were used to assess barrier structure/function. The LPS-cytokines altered expression of multiple proteins that influence innate immunity and promote inflammation. Most of these were unaffected by the multi-mineral intervention, though a subset of inflammation-related proteins including fibrinogen-b and -g chains, phospholipase A2 and SPARC was down-regulated in the presence of the multi-mineral intervention; another subset of proteins with anti-inflammatory, antioxidant or anti-microbial activity was up-regulated by multi-mineral treatment. When used alone, the multi-mineral intervention strongly up-regulated proteins that contribute to barrier formation and tissue strength. Concomitant treatment with LPS-cytokines did not inhibit barrier formation in response to the multi-mineral intervention.

2023-06-30 | PXD038941 | Pride

Mouse colon organoids treated with inflammatory reagents.

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-06-25 | GSE153178 | GEO

Gene expression of UC organoids and UC model organoids (long-term inflammation model) derived from human colonic organoids

Project description:Gene expression changes of human colon orgnaoids by 60weeks of inflammatory stimulation in vitro (long-term inflammed organoids) and after 10weeks from the removal of stimulation (inflammation-removed organoids). GSEA analysis was performed about RNA1-9 (Organoids #1). For the reproducibility of the analysis, GSEA was performed in triplicate. The key molecule for long-term inflammation was extracted from RNA10-12 (Organoids #2). The comparison of gene expression of organoids derived from normal(RNA1-3) and UC mucosa(RNA13-15). For the reproducibility, the analysis was performed in triplicate.

2020-10-26 | GSE156806 | GEO

RNA-seq of BRAF-V600E_mutated and BRAF-V600E_corrected colon cancer organoids

Project description:We aimed to investigate transcriptional changes in human colon cancer organoids with the BRAF-V600E mutation and in human colon cancer organoids in which the BRAF-V600E mutation was corrected by means of CRISPR genome editing. RNAseq was performed at USEQ at the UMC Utrecht (The Netherlands).

2024-02-21 | E-MTAB-13806 | biostudies-arrayexpress

Bulk RNA-seq of MilliporeSigma SCC300 human iPSC-derived colon organoids compared with undifferentiated human iPSCs and MilliporeSigma SCC321 human patient-derived colon organoids

Project description:Experiment intended to obtain expression profiles of iPSC-derived human colon organoids compared to undifferentiated human iPSCs and a patient-derived colon organoid line

2021-10-25 | E-MTAB-11026 | biostudies-arrayexpress

Functional genomics of human colon organoids

Project description:Functional genomics of human colon organoids

| PRJNA589838 | ENA