Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [Set3]

ABSTRACT: An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [Set3]

PROVIDER: PRJNA646636 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

An epigenetic program established by gene - environment interactions initiates pancreatic carcinogenesis

Project description:An epigenetic program established by gene - environment interactions initiates pancreatic carcinogenesis

| PRJNA547618 | ENA

An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [Set1]

Project description:An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [Set1]

| PRJNA547612 | ENA

An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [Set2]

Project description:An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [Set2]

| PRJNA547617 | ENA

An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [ATACSeq_rIL33]

Project description:An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [ATACSeq_rIL33]

| PRJNA681614 | ENA

An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [ATACSeq_shBrd4]

Project description:An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [ATACSeq_shBrd4]

| PRJNA681615 | ENA

An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [ATAC-seq]

Project description:An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [ATAC-seq]

| PRJNA548087 | ENA

An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [scATAC-Seq]

Project description:An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [scATAC-Seq]

| PRJNA564503 | ENA

An epigenetic program established by gene - environment interactions initiates pancreatic carcinogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-11-24 | GSE132330 | GEO

An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [ATACSeq_shBrd4]

Project description:Damaged tissues have increased risk of cancer development through poorly understood mechanisms. In the pancreas, tissue damage collaborates with activating mutations in the Kras oncogene to dramatically accelerate the formation of early neoplastic lesions and ultimately pancreatic cancer. By integrating genomics, single-cell chromatin assays and spatiotemporally-controlled functional perturbations in autochthonous mouse models, we show that the combination of Kras mutation and tissue damage promotes a unique chromatin state in the pancreatic epithelium that distinguishes neoplastic transformation from normal regeneration and is selected for throughout malignant evolution. This cancer-associated epigenetic state emerges within 48 hours of pancreatic injury, and involves large-scale chromatin accessibility changes that contribute to the early dysregulation of genes defining human pancreatic cancer. Among the genes most rapidly activated by tissue damage in the pre-malignant pancreatic epithelium is the alarmin cytokine IL33, which cooperates with mutant Kras in unleashing the epigenetic remodeling program of early neoplasia and neoplastic transformation in the absence of injury. Collectively, our study demonstrates how gene-environment interactions can rapidly produce gene regulatory programs that dictate early neoplastic commitment and provides a molecular framework for understanding the interplay between genetics and environmental cues in cancer initiation.

2021-07-13 | GSE162368 | GEO

An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [ATACSeq_rIL33]

2021-07-13 | GSE162367 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data