Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of the acute and chronic administration of Lupinus albus β-conglutin on glycaemia, circulating cholesterol, and liver gene expression profile

ABSTRACT: Effect of the acute and chronic administration of Lupinus albus β-conglutin on glycaemia, circulating cholesterol, and liver gene expression profile

PROVIDER: PRJNA658370 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Lupinus albus

Project description:Lupinus albus overview

| PRJNA182554 | ENA

Effect of the acute and chronic administration of Lupinus albus β-conglutin on glycaemia, circulating cholesterol, and liver gene expression profile

Project description:Effect of the acute and chronic administration of Lupinus albus β-conglutin on glycaemia, circulating cholesterol, and liver gene expression profile

| PRJNA658370 | ENA

RNA-seq of coding RNA from cluster roots (pre-emergent, juvenile and mature) from Lupinus albus grown for 20 days under phosphorus-deficiency

Project description:RNA-seq analysis was performed on different developmental stages of cluster roots (pre-emergent, juvenile and mature) from Lupinus albus grown for 20 days under phosphorus-deficiency

2014-07-01 | E-MTAB-2253 | biostudies-arrayexpress

Lupinus albus

Project description:Lupinus albus pangenome sequencing and assembly

| PRJNA608889 | ENA

Lupinus albus breed:Lupinus albus L. | cultivar:Amiga

Project description:Lupinus albus breed:Lupinus albus L. | cultivar:Amiga Genome sequencing and assembly

| PRJNA558879 | ENA

Lupinus albus breed:Lupinus albus L. | cultivar:Amiga

Project description:Lupinus albus breed:Lupinus albus L. | cultivar:Amiga Genome sequencing and assembly

| PRJNA558877 | ENA

Effect of the acute and chronic administration of Lupinus albus β-conglutin on glycaemia, circulating cholesterol, and liver gene expression profile

Project description:Constituents of lupin seeds, like γ-conglutin and lupanine, have gained attention as potential complementary treatments for the management of dysglycaemia. Notwithstanding, the effect of other lupin components on carbohydrate metabolism, including β-conglutin protein, has received little attention. Here, we investigated the influence of the acute and chronic administration of β-conglutin on glycaemia modulation in normal and streptozotocin induced-to-diabetes rats. To identify potential molecular targets and pathways involved in this biological response, we analysed the liver transcriptome modulation exerted by β-conglutin in diabetes-induced rats using DNA microarrays. The acute administration of β-conglutin reduced the incremental area under the curve of glycaemia in normal and diabetes-induced animals. In a seven-day study with diabetic animals, glycaemia increased significantly in non-treated animals but remained unchanged in animals treated with a daily dose of β-conglutin. Noteworthy, total cholesterol was significantly lower at the end of the experimental period (−21.8%, p = 0.039). Results of the microarray test and gene ontology analyses revealed several targets and pathways modulated after β-conglutin treatment, including a down-regulation of Jun kinase activity. Moreover, our data indicate that targets related to oxidative stress, inflammation, and estrogenic activity might orchestrate these metabolic effects. In conclusion, our findings show that β-conglutin may be useful to manage postprandial glycaemia and reduce cholesterol levels under the dysglycaemia stage. We identified and proposed new potential molecular targets for further research related to the mechanism of action of β-conglutin.

2020-08-21 | GSE156579 | GEO

Lupinus albus

Project description:Lupinus albus genome-wide association study for phenology traits

| PRJNA939025 | ENA

Proteome remodeling and amino acid metabolism during germination and seedling establishment in Lupinus albus

Project description:During germination and early seedling development plants rely entirely on their seed storage compounds to provide energy and precursors for the synthesis of macromolecular structures such as cell walls until the seedling has emerged from the soil and photosynthesis can be established. Lupin seeds use proteins as their major storage compounds, accounting for up to 40% of the seed dry weight. Lupins are therefore a valuable complement to soy as a source of plant protein for human and animal nutrition. However, knowledge on protein and amino acid metabolism during germination and seedling establishment in lupin plants is still limited. The aim of this study was to elucidate how storage protein metabolism is coordinated with other metabolic processes to meet the requirements of the growing seedling. In a quantitative approach, we analyzed seedling growth, as well as alterations in biomass composition, the proteome, and metabolite profiles during germination and seedling establishment in Lupinus albus. The reallocation of nitrogen resources from seed storage proteins to functional seed proteins was mapped based on a manually curated functional protein annotation database. Although classified as a protein crop, Lupinus albus does not use amino acids as a primary resource during germination. The predominant role of the stored proteins is to act as a nitrogen resource for vigorous post-germinative growth. The degradation of storage lipids and carbohydrates is sufficient to meet the energy requirements for early seedling establishment until the onset of photosynthesis. However, our results suggest that during germination fatty acid and amino acid metabolism may be integrated at the level of malate synthase to combine stored carbon from lipids and proteins into gluconeogenesis.

2024-07-26 | PXD046789 | Pride

Lupinus albus cultivar:AMIGA

Project description:Lupinus albus cluster root spatial RNA-seq

| PRJNA593912 | ENA