Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Changes of gene expression patterns of mouse lung epithelial cells in response to IL-15 whether or not they have MCMV-memory CD8 T cells [mouse in vivo]

ABSTRACT: Changes of gene expression patterns of mouse lung epithelial cells in response to IL-15 whether or not they have MCMV-memory CD8 T cells [mouse in vivo]

PROVIDER: PRJNA658488 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12491367.fastq.gz	Fastqsanger.gz
	SRR12491368.fastq.gz	Fastqsanger.gz
	SRR12491369.fastq.gz	Fastqsanger.gz
	SRR12491370.fastq.gz	Fastqsanger.gz
	SRR12491371.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 13

Similar Datasets

Changes of gene expression patterns of mouse lung CD45- cells in response to IL-15/IL-15Ra complex whether or not they have MCMV-memory CD8 T cells

Project description:We report the differences of gene expression pattern of 4 different groups of mouse lung CD45- cells (Naive mouse without IL-15/IL-15Ra complex, Naive mouse with IL-15/IL-15Ra complex, MCMV-infected mouse without IL-15/IL-15Ra complex, and MCMV-infected mouse with IL-15/IL-15Ra complex). We found that mouse with MCMV-memory CD8 T cells response to IL-15/IL-15Ra complex and the behaviors of cancer were changed compared to other groups.

2021-10-06 | GSE185243 | GEO

Changes of gene expression patterns of mouse lung epithelial cells in response to IL-15 whether or not they have MCMV-memory CD8 T cells [mouse in vivo]

Project description:We report the differences of gene expression pattern of 4 different groups of mouse lung epithelial cells (Naive mouse without IL-15, Naive mouse with IL-15, MCMV-infected mouse without IL-15, and MCMV-infected mouse with IL-15). We found that mouse with MCMV-memory CD8 T cells response to IL-15 and the behaviors of cancer were changed compared to other groups.

2020-08-22 | GSE156605 | GEO

Changes of gene expression patterns of mouse lung CD45- cells in response to IL-15/IL-15Ra complex whether or not they have MCMV-memory CD8 T cells

Project description:Changes of gene expression patterns of mouse lung CD45- cells in response to IL-15/IL-15Ra complex whether or not they have MCMV-memory CD8 T cells

| PRJNA768389 | ENA

MCMV infection of cultured mouse cells induces expression of miR-7a.

Project description:One goal of viral infection is to reprogram the host cell to optimize viral replication. As part of this process, viral miRNAs may compete for components of the miRNA/siRNA pathway as well as regulate cellular targets. Mouse Cytomegalovirus has been described to generate large numbers of viral miRNAs during lytic infection and was therefore used to analyze the impact of viral miRNAs on the host cell small RNA system as well as to check for sorting of viral small RNAs into specific Ago-proteins. Deep sequencing analysis of MCMV infected cells revealed that viral miRNAs represent only app. 13% of all detected miRNAs. All previously described MCMV miRNAs with the exception of miR-m88-1* were confirmed and for the MCMV miR-m01-1 hairpin an additional miRNA, designated miR-m01-1-3p, was found. Its presence was confirmed by qPCR and Northern Blot. Deep sequencing after RISC IP with antibodies specific for either Ago1 or Ago2 showed that all MCMV miRNAs are loaded into both RISC complexes. The ratio of MCMV to mouse miRNAs was not increased after immunoprecipitation of Ago-proteins. Viral miRNAs therefore do not overwhelm the host miRNA processing system nor are they preferentially incorporated into RISC. We found that 3 mouse miRNAs showed an altered expression due to MCMV infection. Down-regulation of miR-27a, as previously described, could be confirmed. In addition, miR-26a was down-regulated and an up-regulation of miR-7a dependent on viral protein expression could be observed. Examination of small RNA expression in uninfected vs. infected cells, immunoprecipitation + sequencing of Ago1 and Ago2 loaded small RNAs in infected cells

2012-06-30 | E-GEOD-36919 | biostudies-arrayexpress

MCMV infection of cultured mouse cells induces expression of miR-7a.

2012-07-01 | GSE36919 | GEO

MCMV-experienced ILC1 acquire an m12-dependent memory response

Project description:Innate and adaptive immune cells can acquire “memory” of encounters with a diverse range of activating signals to tune their response to secondary stimuli. Group 1 innate lymphoid cells (ILC1) are recently discovered tissue-resident sentinels that are essential for early host protection from intracellular pathogens at initial sites of infection. However, whether ILC1 function as short-lived effectors or persist and refine their responsiveness following pathogen challenge is not well understood. Furthermore, whether pathogen-derived antigens directly modulate tissue-resident ILC responses remains unclear. Here, we found that liver-resident ILC1 expand locally and persist following the resolution of mouse cytomegalovirus (MCMV) infection. MCMVexperienced ILC1 acquired stable transcriptional, epigenetic, and phenotypic changes, with an enhanced protective effector response to secondary MCMV challenge. Protective memory ILC1 responses were dependent on the MCMV-encoded glycoprotein m12, but not formed during bystander cytokine activation following heterologous infection. Thus, liver ILC1 acquire adaptive features in a MCMV-specific manner.

2019-05-02 | GSE128906 | GEO

Mouse microglial MCMV infection

Project description:NK cells mediate neuroinflammation and brain pathology following congenital MCMV infection

| PRJEB38849 | ENA

Expression data for MCMV-treated compared to Mock-treated Mut3 neurospheres

Project description:MCMV has been reported to infect neural stem cells in the subventricular zone. These same cells have been shown to give rise to gliomas. We wanted to test expression levels of RNA in this cell population after MCMV infection in a mouse model of glioma.

2015-09-28 | GSE32454 | GEO

cRNA-seq of MCMV

Project description:Swiss murine embryonic fibroblasts (NIH-3T3) were infected with wild-type Smith strain mouse cytomegalovirus (MCMV) at a multiplicity of infection (MOI) of 10. Sequencing libraries were prepared using the cRNA-seq protocol from the indicated time points of infection as described by Whisnant A.W. et al, Nat. Commun (2020)

2023-04-26 | GSE212285 | GEO

scRNA-Seq of negatively enriched NK cells 4 days post MCMV infection

Project description:Ly49G2+ NK cells mediate essential control of murine cytomegalovirus (MCMV) infection in mice which express the H-2Dk class I molecule. As a cognate ligand for specific Ly49G2 inhibitory receptor allotypes, H-2Dk also licenses Ly49G2+ NK cells in naïve and MCMV-infected mice. These findings suggest Ly49G2 may promote antiviral NK cell activities during MCMV infection. Indeed, in mice lacking the Ly49G2 receptor, MCMV resistance is fully abrogated. Additionally, NK cells expressing Ly49R, an NK cell associated activation receptor that also recognizes H-2Dk, have their function augmented by Ly49G2 and are required for MCMV resistance.

2019-12-11 | GSE132394 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data