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Macrophage Gene Expression in PyMT Tumor Progression

ABSTRACT: Macrophage Gene Expression in PyMT Tumor Progression

PROVIDER: PRJNA660767 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12564959.fastq.gz	Fastqsanger.gz
	SRR12564960.fastq.gz	Fastqsanger.gz
	SRR12564961.fastq.gz	Fastqsanger.gz
	SRR12564962.fastq.gz	Fastqsanger.gz
	SRR12564963.fastq.gz	Fastqsanger.gz

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Macrophage Gene Expression in PyMT Tumor Progression

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Project description:Junction Adhesion Molecule-A (JAM-A) is present on leukocytes and platelets where it promotes cell adhesion and motility. We are interested in an interaction between JAM-A and tumor progression/metastases. To address this point, we mated JAM-A-/- mice and mouse mammary tumor model MMTV-PyMT mice which, which express polyoma middle T antigen under the control of mouse mammary tumor virus. MMTV-PyMT mice show 100% penetration of mammary tumor and highly metastases to lung. MMTV-PyMT mice without JAM-A show less primary tumor progression, therefore JAM-A enhance primary tumor progression. Then we are addressing the molecular mechanism of this phenomenon by in vivo. Furthermore, we would like to examine JAM-A deficient MMTV tumor signature. Each 3 MMTV-PyMT JAm-A+/+ (JamA+) and 3 MMTV JAM-A-/- (JamA-) mammary tumor were resected at early stages of tumor development for RNA extraction and hybridization on Affymetrix microarrays.

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