Ontology highlight
ABSTRACT:
PROVIDER: PRJNA662839 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Cane toad (Rhinella marina) pooled liver transcriptome
| PRJNA419245 | ENA
Project description:Native-range and invasive Rhinella marina Raw sequence reads
| PRJNA510261 | ENA
Project description:De novo whole genome sequencing and assembly of the invasive cane toad, Rhinella marina
| PRJEB24695 | ENA
Project description:Multi-tissue RNA-seq from the african lungfish (Protopterus sp), the cane toad (Rhinella marina) and the pond slider (Trachemys scripta)
| PRJEB21481 | ENA
Project description:Rhinella marina (cane toad, formerly Bufo marinus) spleen transcriptome sequenced for characterisation of immune genes.
| PRJEB9695 | ENA
Project description:Boreal toads (Anaxyrus boreas boreas) of the Southern Rocky Mountain population are declining due to the introduction of the chytrid fungus Batrachochytrium dendrobatidis (Bd). Boreal toads in Colorado are generally susceptible to Bd infection, but some Bd-tolerant populations persist in parts of the Southern Rocky Mountain and broader Eastern boreal toad population. We conducted a Bd challenge with lab-reared sibling toads from Bd-susceptible Colorado and purportedly Bd-tolerant Utah populations and report on transcriptomic responses to Bd during late infection in skin and liver tissue. Fewer immune genes were expressed in response to Bd in Colorado toads, but with greater upregulation compared to Utah toads, indicating a dysregulated immune response. Signatures of Bd-tolerance in Utah toads included more moderate upregulation in immune gene expression and a significantly enriched suite of gene functions related to innate and adaptive immune responses. Our transcriptomic results support the notion that Utah toads are tolerant to Bd, rather than resistant, carrying Bd loads similar to Colorado yet having a unique transcriptomic profile and presenting minimal clinical signs of chytridiomycosis. We conclude that closely related populations have divergent transcriptomic responses to Bd with a dysregulated immune response in Bd-susceptible toads.
2023-10-04 | GSE244617 | GEO