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Single-cell transcriptomic landscape reveals the differences in cell differentiation and immune microenvironment of papillary thyroid carcinoma between male and female patients

ABSTRACT: Single-cell transcriptomic landscape reveals the differences in cell differentiation and immune microenvironment of papillary thyroid carcinoma between male and female patients

PROVIDER: PRJNA664760 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12682742_1.fastq.gz	Fastqsanger.gz
	SRR12682742_2.fastq.gz	Fastqsanger.gz
	SRR12682743_1.fastq.gz	Fastqsanger.gz
	SRR12682743_2.fastq.gz	Fastqsanger.gz
	SRR12682744_1.fastq.gz	Fastqsanger.gz

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Single-cell transcriptomic landscape reveals the differences in cell differentiation and immune microenvironment of papillary thyroid carcinoma between male and female patients

Project description:Objective: Papillary thyroid carcinoma (PTC) is the main pathological type of thyroid carcinoma (TC), whose incidence and prognosis are related to the gender of patients. We focused on the differences of cell clusters and immune microenvironment induced by gender in PTC. Methods: We collected tissues from nodular goiter, male PTC patients and female PTC patients respectively, performed single-cell RNA sequencing (scRNA-seq) based on BD Rhapsody and characterized the first single-cell transcriptomic landscape of PTC involving gender. The differential cell clusters and their genes profile were identified in male- and female- PTC, analyzed by multi-resolution network. Finally, we analyzed the interaction of fibroblasts, endothelial cells with malignant epithelial cells, and the difference of immune infiltration of B lymphocytes and T lymphocytes driven by gender. Results: Malignant epithelial cells were divided into two distinct subsets in male PTC patients and female PTC patients, with significant difference involving gene mutation, gene profile and cell differentiation. In the interaction between fibroblasts, endothelial cells and malignant epithelial cells, members of human leukocyte antigen and their receptors were considered as typical in female PTC patients, while TGFB1 and its receptors in male PTC patients. Both B cells and T cells were significantly different between male- and female PTC patients, involving cell clusters, cell differentiation and dominant genes set. Conclusions: Our research indicated the detailed differences of cell clusters and immune microenvironment in PTC driven by gender, and provided an insight to further understand the impact of gender on PTC at single-cell level.

2020-12-31 | GSE158291 | GEO

Human papillary thyroid carcinoma landscape and its immunological link with Hashimoto's thyroiditis at single cell resolution

Project description:Tumor microenvironment heterogeneity sheltered our understanding of papillary thyroid cancer. However, molecular characteristics of papillary thyroid cancer has not been reported at single cell resolution. The immunological link between papillary thyroid cancer and Hashimoto's thyroiditis is also in doubt.We identified 24 cell clusters in human papillary thyroid cancer based on their heterogeneous gene expression pattern. Follicular epithelial cell subsets in papillary thyroid cancer with Hashimoto's thyroiditis and papillary thyroid cancer without Hashimoto's thyroiditis showed different malignant level. Machine learning model identified potential biomarker to evaluate tumor epithelial cell development. Together with immunostaining, lymphocytes heterogeneity indicated an obvious B cell infiltration pattern in papillary thyroid cancer with Hashimoto's thyroiditis. Additionally, trajectory analysis of B cell and plasma cell suggest the migration potential from normal adjacent tissue of Hashimoto's thyroiditis to papillary thyroid cancer tissue. Our results provide the first single cell landscape of Papillary thyroid cancer. Single cell data resource of Papillary thyroid cancer with Hashimoto's thyroiditis promote our understanding of molecular heterogeneity and immunological link between papillary thyroid cancer and Hashimoto's thyroiditis.

2021-07-01 | GSE163203 | GEO

Papillary thyroid cancer proteomics

Project description:Label-free proteomics profiling of 37 paired tumor-normal tissues of papillary thyroid cancer

2024-02-08 | PXD044900 | Pride

Dissecting the transcriptomic landscape of the human papillary thyroid carcinoma by single cell RNA-sequencing

Project description:Papillary thyroid carcinoma (PTC) is the most common malignant phenotype of thyroid cancer, with a rapidly increasing number of new cases globally. Multifocality is a common phenomenon in patients with PTC. The tumor microenvironment (TME) plays a pivotal role in cancer progression in papillary thyroid carcinoma (PTC), yet the composition and phenotype of cells within TME in bilateral PTCs are poorly understood.

2022-04-13 | GSE191288 | GEO

Papillary thyroid cancer cell lines treated with Y15

Project description:3 papillary thyroid cancer cell lines were compared, treated with Y15 to untreated. 1 million cells of each papillary thyroid cell line (TPC1, K1, BCPAP) were plated, treated 24 hours later with 10uM Y15, and collected 24 hours later by trypsinization.

2014-03-06 | E-GEOD-55603 | biostudies-arrayexpress

Sporadic and Post-Chernobyl Papillary Thyroid Cancers

Project description:We compared the expression profiles of papillary thyroid tumors from the Chernobyl Tissues Bank (CTB) with tumors from French patients with no history of exposure to radiations. Keywords: papillary thyroid cancer vs. patient-matched healthy adjacent thyroid thyroid papillary cancer vs. patient-matched adjacent nontumor thyroid tissues. -14 tumors from France -12 tumors from Ukraine

2007-07-11 | E-GEOD-3950 | biostudies-arrayexpress

Papillary thyroid cancer phosphorylated proteomics

Project description:Phosphorylated proteomics profiling were performed on 37 paired tumor-normal tissues of human papillary thyroid cancer

2024-02-08 | PXD045017 | Pride

Sporadic and Post-Chernobyl Papillary Thyroid Cancers

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Papillary thyroid cancer cell lines treated with Y15

Project description:3 papillary thyroid cancer cell lines were compared, treated with Y15 to untreated.

2014-03-06 | GSE55603 | GEO

Gene signature of the post-Chernobyl papillary thyroid cancer

Project description:Thyroid gland is among the most sensitive organs to ionizing radiation. Whether low-dose radiation-induced papillary thyroid cancer (PTC) differs from sporadic PTC is yet unknown. We used microarrays to identify gene signature of radiation-induced papillary thyroid carcinomas

2015-12-31 | GSE35570 | GEO

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