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RNA resequencing of liver in macrophage-specific-Pparg knockout mice model

ABSTRACT: RNA resequencing of liver in macrophage-specific-Pparg knockout mice model

PROVIDER: PRJNA673131 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12931419_1.fastq.gz	Fastqsanger.gz
	SRR12931419_2.fastq.gz	Fastqsanger.gz
	SRR12931420_1.fastq.gz	Fastqsanger.gz
	SRR12931420_2.fastq.gz	Fastqsanger.gz
	SRR12931421_1.fastq.gz	Fastqsanger.gz

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RNA resequencing of liver in macrophage-specific-Pparg knockout mice model

Project description:Wild type and macrophage-specific-Pparg knockout C57 mice were gavaged with CMC or DEHP for 28 or 90continuous days. At the end of the experiment, livers were harvested for RNA-seq. Data analysis revealed that DEHP induced remarkable changes of lipid metabolic genes in liver, and that loss of Pparg in hepatic macrophages significantly abrogated the elevation of gene overexpression associated with fatty acid metabolism.

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Project description:This SuperSeries is composed of the following subset Series: GSE16385: Expression data from human macrophages GSE16386: Expression data from human alternatively activated macrophages GSE25088: PPARg and IL-4-induced gene expression data from wild-type and STAT6 knockout mouse bone marrow-derived macrophages GSE25123: PPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived macrophages GSE25125: PPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived alternatively activated macrophages and immature dendritic cells (iDCs) Refer to individual Series

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