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Chamber-Enriched gene expression profiles in failing human hearts with reduced ejection fraction [snRNA-Seq]

ABSTRACT: Chamber-Enriched gene expression profiles in failing human hearts with reduced ejection fraction [snRNA-Seq]

PROVIDER: PRJNA678355 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13057934.fastq.gz	Fastqsanger.gz
	SRR13057935.fastq.gz	Fastqsanger.gz
	SRR13057936.fastq.gz	Fastqsanger.gz
	SRR13057937.fastq.gz	Fastqsanger.gz
	SRR14513863_1.fastq.gz	Fastqsanger.gz

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Chamber-Enriched gene expression profiles in failing human hearts with reduced ejection fraction [snRNA-Seq]

Project description:To generate the reference for cell composition deconvolution and characterize the cellular expression landscape, we performed single nucleus RNA-Seq (snRNA-Seq) on left ventricles from four non-failing hearts and one failing heart.

2021-06-04 | GSE161470 | GEO

Chamber-Enriched gene expression profiles in failing human hearts with reduced ejection fraction [RNA-Seq]

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Chamber-Enriched gene expression profiles in failing human hearts with reduced ejection fraction

Project description:Chamber-Enriched gene expression profiles in failing human hearts with reduced ejection fraction

| PRJNA678357 | ENA

Chamber-Enriched gene expression profiles in failing human hearts with reduced ejection fraction [RNA-Seq]

Project description:Chamber-Enriched gene expression profiles in failing human hearts with reduced ejection fraction [RNA-Seq]

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Single nuclei sequencing of human and Mice HFrEF data (Heart Failure with reduced ejection fraction)

Project description:Here we provide snRNA-seq datasets from heart failure patients with reduced ejection fraction and snRNA-SEQ of the corresponding LAD mouse model (permanent ligation of the left anterior descending artery)

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Chamber-enriched gene expression profiles in failing human hearts with reduced ejection fraction.

Project description:Heart failure with reduced ejection fraction (HFrEF) constitutes 50% of HF hospitalizations and is characterized by high rates of mortality. To explore the underlying mechanisms of HFrEF etiology and progression, we studied the molecular and cellular differences in four chambers of non-failing (NF, n = 10) and HFrEF (n = 12) human hearts. We identified 333 genes enriched within NF heart subregions and often associated with cardiovascular disease GWAS variants. Expression analysis of HFrEF tissues revealed extensive disease-associated transcriptional and signaling alterations in left atrium (LA) and left ventricle (LV). Common left heart HFrEF pathologies included mitochondrial dysfunction, cardiac hypertrophy and fibrosis. Oxidative stress and cardiac necrosis pathways were prominent within LV, whereas TGF-beta signaling was evident within LA. Cell type composition was estimated by deconvolution and revealed that HFrEF samples had smaller percentage of cardiomyocytes within the left heart, higher representation of fibroblasts within LA and perivascular cells within the left heart relative to NF samples. We identified essential modules associated with HFrEF pathology and linked transcriptome discoveries with human genetics findings. This study contributes to a growing body of knowledge describing chamber-specific transcriptomics and revealed genes and pathways that are associated with heart failure pathophysiology, which may aid in therapeutic target discovery.

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Chamber-Enriched gene expression profiles in failing human hearts with reduced ejection fraction

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-04 | GSE161473 | GEO

Molecular and Cellular Mechanisms of Heart Failure With Preserved Ejection Fraction

Project description:To understand the cellular mechanisms of heart failure with preserved ejection fraction (HFpEF), We investigated the functional outcome and the underlying mechanisms from concurrent mechanic and metabolic stresses in the heart by applying transverse aortic constriction (TAC) in lean C57Bl/6J (HFrEF phenotype) or obese/diabetic B6.Cg-Lepob/J (ob/ob) mice (HFpEF phenotype) followed by single-nuclei RNA-seq (snRNA-seq) and targeted manipulation of a top ranked signaling pathway (glucagon receptor signaling) differentially affected in the two experimental cohorts.

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Myeloid Cell Derived IL1b Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection Fraction

Project description:Goals and objectives of this study were to determine by bulk RNA-sequencing transcriptomic changes that occur in the lungs of a murine model of heart failure with preserved ejection fraction caused by administration of high fat diet and eNOS inhibitor L-NAME.

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