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Coordination of two enhancers drives expression of olfactory trace amine-associated receptors VII

ABSTRACT: Coordination of two enhancers drives expression of olfactory trace amine-associated receptors VII

PROVIDER: PRJNA687515 | ENA |

REPOSITORIES: ENA

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Coordination of two enhancers drives expression of olfactory trace amine-associated receptors VII

Project description:Olfactory sensory neurons (OSNs) are functionally defined by their expression of a unique odorant receptor (OR). Mechanisms underlying singular OR expression are well studied, and involve a massive cross-chromosomal enhancer interaction network. Trace amine-associated receptors (TAARs) form a distinct family of olfactory receptors, and here we find that mechanisms regulating Taar gene choice display many unique features. The epigenetic signature of Taar genes in TAAR OSNs is different from that in OR OSNs. We further identify that two TAAR enhancers conserved across placental mammals are absolutely required for expression of the entire Taar gene repertoire. Deletion of either enhancer dramatically decreases the expression probabilities of different Taar genes, while deletion of both enhancers completely eliminates the TAAR OSN populations. In addition, both of the enhancers are sufficient to drive transgene expression in the partially overlapped TAAR OSNs. We also show that the TAAR enhancers operate in cis to regulate Taar gene expression. Our findings reveal a coordinated control of Taar gene choice in OSNs by two remote enhancers, and provide an excellent model to study molecular mechanisms underlying formation of an olfactory subsystem.

2021-03-08 | GSE163776 | GEO

Coordination of two enhancers drives expression of olfactory trace amine-associated receptors

Project description:Coordination of two enhancers drives expression of olfactory trace amine-associated receptors

| PRJNA687507 | ENA

Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers

Project description:Our study shows reduced expression of Trace-Amine Associated Receptors (TAARs) in the olfactory epithelium of mice in which Taar elements 1 and 2 (TE1+2) are deleted in cis.

2021-04-01 | GSE171241 | GEO

Coordination of two enhancers drives expression of olfactory trace amine-associated receptors V

Project description:Coordination of two enhancers drives expression of olfactory trace amine-associated receptors V

| PRJNA687037 | ENA

Coordination of two enhancers drives expression of olfactory trace amine-associated receptors VIII

Project description:Coordination of two enhancers drives expression of olfactory trace amine-associated receptors VIII

| PRJNA691055 | ENA

Coordination of two enhancers drives expression of olfactory trace amine-associated receptors VI

Project description:Coordination of two enhancers drives expression of olfactory trace amine-associated receptors VI

| PRJNA687251 | ENA

Coordination of two enhancers drives expression of olfactory trace amine-associated receptors I

Project description:Coordination of two enhancers drives expression of olfactory trace amine-associated receptors I

| PRJNA687021 | ENA

Coordination of two enhancers drives expression of olfactory trace amine-associated receptors II

Project description:Coordination of two enhancers drives expression of olfactory trace amine-associated receptors II

| PRJNA687023 | ENA

Coordination of two enhancers drives expression of olfactory trace amine-associated receptors III

Project description:Coordination of two enhancers drives expression of olfactory trace amine-associated receptors III

| PRJNA687029 | ENA

Coordination of two enhancers drives expression of olfactory trace amine-associated receptors IV

Project description:Coordination of two enhancers drives expression of olfactory trace amine-associated receptors IV

| PRJNA687032 | ENA

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