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The developmental impacts of natural selection on human pelvic morphology

ABSTRACT: The developmental impacts of natural selection on human pelvic morphology

PROVIDER: PRJNA698611 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13603000_1.fastq.gz	Fastqsanger.gz
	SRR13603000_2.fastq.gz	Fastqsanger.gz
	SRR13603001_1.fastq.gz	Fastqsanger.gz
	SRR13603001_2.fastq.gz	Fastqsanger.gz
	SRR13603002_1.fastq.gz	Fastqsanger.gz

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Project description:Failure of ligamentous support of the genital tract to resist intra-abdominal pressure is a plausible underlying mechanism for the development of pelvic organ prolapse, but the nature of molecular response of pelvic tissue support remains unknown. We hypothesized that the expression of genes coding for proteins involved in maintaining the cellular and extracellular integrity would be altered in cases of pelvic organ prolapse. Therefore, cDNA microarrays were used to examine the difference in transcriptional profile in RNA of primary culture fibroblasts subjected to mechanical stretch and those that remained static. Keywords: Changes in transcription profile in pelvic organ fibroblasts in response to stretch

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