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DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy [array]

ABSTRACT: DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy [array]

PROVIDER: PRJNA699176 | ENA |

REPOSITORIES: ENA

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DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy [array]

Project description:This study profiled the epigenomes and transcriptomes of total B cell populations from adolescents with peanut-only (single food allergy- SA) and multi-food allergy (MA). We found distinct epigenetic and transcriptomic differences between food allergic patients and controls, in addition to SA- and MA- group specific signatures, with

2021-09-01 | GSE166067 | GEO

DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy [RNA-Seq]

Project description:This study profiled the epigenomes and transcriptomes of total B cell populations from adolescents with peanut-only (single food allergy- SA) and multi-food allergy (MA).

2021-09-01 | GSE165316 | GEO

DNA methylation and transcriptomic signatures in patients with peanut- and multi-food allergy (Methylation)

Project description:This study profiled the epigenomes and transcriptomes of total nCD4T cell populations from adolescents with peanut-only (single food allergy- SA) and multi-food allergy (MA) at quiescence and following activation with anti-CD3/antiCD28

2022-02-28 | GSE189148 | GEO

DNA methylation and transcriptomic signatures in patients with peanut- and multi-food allergy (RNA-Seq)

2022-02-28 | GSE189149 | GEO

DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy

Project description:DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy

| PRJNA699173 | ENA

DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy [RNA-Seq]

Project description:DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy [RNA-Seq]

| PRJNA694065 | ENA

Ar101 Oral Desensitization Therapy for Peanut Allergy Induces Dynamic Changes in Peanut-Specific Immune Responses

Project description:Peanut allergy is increasingly prevalent among children in the United States and other industrialized countries and is now estimated to affect approximately 2% of children. While there are currently no approved treatment options, peanut allergy usually persists into adulthood, can be life-threatening, and accounts for most deaths related to food allergy. Here, we track peanut-reactive CD4+ T effector (pTeff) cells using the CD154 up-regulation assay. We found that CRTH2+ pTeff cells and CCR6+ pTeff cells represent two mutually exclusive, non-overlapping cellular and molecular entities involved in food allergic diseases.

2022-08-10 | GSE196495 | GEO

DNA methylation and transciptomic signatures in patients with peanut- and multi-food allergy

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-09-02 | GSE166068 | GEO

Antibody repertoires in peanut allergy

Project description:Antibody repertoires in peanut allergy

| PRJNA378451 | ENA

CC027/GeniUnc mouse strain-derived jejunal epithelial cells before and after peanut sensitization and at 30, 60, and 120 minutes after peanut challenge

Project description:Peanut allergy reaction severity correlates with increased intestinal epithelial cell (IEC) barrier permeability. CC027/GeniUnc mice develop peanut allergy by intragastric administration of peanut proteins without adjuvant. We report that peanut-allergic CC027/GeniUnc mice showed increased IEC barrier permeability and systemic peanut allergen Ara h 2 after challenge. Jejunal epithelial cell transcriptomics showed effects of peanut allergy on IEC proliferation, survival, and metabolism, and revealed IEC-predominant angiopoietin like-4 (Angptl4) as a unique feature of CC027/GeniUnc peanut allergy. Peanut-allergic pediatric patients demonstrated significantly higher serum ANGPTL4 compared to non-peanut-allergic but atopic patients, highlighting its potential as a biomarker of peanut allergy.

2021-07-09 | GSE179595 | GEO

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