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Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers

ABSTRACT: Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers

PROVIDER: PRJNA703390 | ENA |

REPOSITORIES: ENA

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Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers [Hi-C]

Project description:Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers [Hi-C]

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Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers [ChIP-seq]

Project description:Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers [ChIP-seq]

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Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers [RNA-seq]

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Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers [ATAC-seq]

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Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers [RNA-seq]

Project description:Triple-negative breast cancer (TNBC) is malignant cancer with a high risk of recurrence. To date, the underlying 3D chromatin organizations of TNBC have remained unclear. Here, using in situ Hi-C, we characterized the 3D chromatin organizations in cells representing five distinct subtypes of breast cancer (including TNBC) and TNBC tissues, compared to normal cells/tissues. We found that the global and local 3D architectures are severely disrupted in TNBC cells. Importantly, we detected CTCF-dependent TNBC-susceptible loss/gain of 3D chromatin organizations and found that these changes were strongly associated with perturbed chromatin accessibility and transcriptional dysregulations. Although some discrepancies exist between TNBC cell lines and tissues, we observed that perturbed local 3D architectures found in TNBC cells are partially conserved in TNBC tissues. Furthermore, we discovered distinct tissue-specific chromatin loops by comparing normal and TNBC tissues. Collectively, our findings provide important features of 3D chromatin organization in TNBC.

2022-05-06 | GSE167152 | GEO

Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers [ChIP-seq]

2022-05-06 | GSE167151 | GEO

Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers [Hi-C]

2022-05-06 | GSE167150 | GEO

Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers [ATAC-seq]

2022-05-06 | GSE167153 | GEO

Comparative Characterization of 3D Chromatin Organization in Triple-Negative Breast Cancers

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-05-06 | GSE167154 | GEO

Transcriptional regulation by Fra-1 in triple negative breast cancers

Project description:This SuperSeries is composed of the SubSeries listed below. All the data are described in the article "Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers" by Bejjani et al.

2021-02-23 | GSE146825 | GEO

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