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Histone acetylation dynamics modulate chromatin conformation and allele-specific interactions at oncogenic loci (Hi-C)

ABSTRACT: Histone acetylation dynamics modulate chromatin conformation and allele-specific interactions at oncogenic loci (Hi-C)

PROVIDER: PRJNA707506 | ENA |

REPOSITORIES: ENA

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Histone acetylation dynamics modulate chromatin conformation and allele-specific interactions at oncogenic loci (Hi-C)

Project description:In cancer cells, enhancer hijacking mediated by chromosomal alterations and/or increase of histone H3 lysine 27 acetylation (H3K27ac) can support oncogene expression. However, how the chromatin conformation of enhancer-promoter interactions is affected by these events is unclear. Here, by comparing chromatin structure and H3K27ac levels in normal and lymphoma B-cells, we show that enhancer-promoter interacting regions assume different conformations according to the local abundance of H3K27ac. Genetic or pharmacologic depletion of H3K27ac decreases the frequency and the spreading of these interactions, altering oncogene expression. Moreover, enhancer hijacking mediated by chromosomal translocations influences the epigenetic status of the regions flanking the breakpoint, prompting the formation of distinct intra-chromosomal interactions in the two homologous chromosomes. These interactions are accompanied by allele-specific gene expression changes. Overall, our work indicates that H3K27ac dynamics modulate interaction frequency between regulatory regions and can lead to allele-specific chromatin configurations to sustain oncogene expression.

2021-03-09 | GSE168470 | GEO

Histone acetylation dynamics modulate chromatin conformation and allele-specific interactions at oncogenic loci.

Project description:Histone acetylation dynamics modulate chromatin conformation and allele-specific interactions at oncogenic loci.

| PRJNA707503 | ENA

Histone acetylation dynamics modulate chromatin conformation and allele-specific interactions at oncogenic loci (ChIPSeq)

2021-03-09 | GSE168472 | GEO

Histone acetylation dynamics modulate chromatin conformation and allele-specific interactions at oncogenic loci (RNASeq)

2021-03-09 | GSE168471 | GEO

Histone acetylation dynamics modulate chromatin conformation and allele-specific interactions at oncogenic loci (ChIPSeq)

Project description:Histone acetylation dynamics modulate chromatin conformation and allele-specific interactions at oncogenic loci (ChIPSeq)

| PRJNA707507 | ENA

Histone acetylation dynamics modulate chromatin conformation and allele-specific interactions at oncogenic loci (RNASeq)

Project description:Histone acetylation dynamics modulate chromatin conformation and allele-specific interactions at oncogenic loci (RNASeq)

| PRJNA707508 | ENA

Histone acetylation dynamics modulate chromatin conformation and allele-specific interactions at oncogenic loci.

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-09 | GSE168474 | GEO

Hi-C of Drosophila embryos to investigate chromatin conformation during dorsal-ventral patterning

Project description:Hi-C was carried out for control embryos and embryos produced from gd7, Tollrm9/rm10, and Toll10B mutant mothers. The embryos from mutant mothers produce only a single type along the dorsal-ventral axis. We used these embryos to compare chromatin conformation across tissues.

2021-01-08 | E-MTAB-9306 | biostudies-arrayexpress

Systematic evaluation of chromosome conformation capture assays [Hi-C]

Project description:Systematic evaluation of chromosome conformation capture assays [Hi-C]

| PRJNA698731 | ENA

Identification of causal genes about osteoporosis associated with risk loci using DLO Hi-C [Hi-C]

Project description:In this project, we use a simple digestion-ligation-only Hi-C (DLO Hi-C) technology, for whole-genome chromosome conformation capture, analysis of genes expression changes and transcriptional regulatory elements involved in BMMSC differentiation. Rely on GWAS data and eQTL analysis, our findings confirmed some previously reported genes that have an effect on OP, such as TIMP-2, MMP-2 and DAAM2, TMEM241 was less reported. Furthermore, our work provide a theoretical basis for the development of OP.

2023-02-08 | GSE160394 | GEO

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