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NSD2 amplifies oncogenic transcriptional output to promote lung adenocarcinoma pathogenesis [CUT&RUN]

ABSTRACT: NSD2 amplifies oncogenic transcriptional output to promote lung adenocarcinoma pathogenesis [CUT&RUN]

PROVIDER: PRJNA718812 | ENA |

REPOSITORIES: ENA

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NSD2 amplifies oncogenic transcriptional output to promote lung adenocarcinoma pathogenesis [CUT&RUN]

Project description:RNA-seq of kras and kras;NSD2 driven tumor biopsies and RNA-seq and Cut-and-run of kras;NSD2 derived cells suggests NSD2 amplifies Ras-output at chromatin and separately activates oncogenic-promoting gene expression programs.

2021-09-21 | GSE171216 | GEO

NSD2 amplifies oncogenic transcriptional output to promote lung adenocarcinoma pathogenesis [RNA-seq]

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NSD2 amplifies oncogenic transcriptional output to promote lung adenocarcinoma pathogenesis

Project description:NSD2 amplifies oncogenic transcriptional output to promote lung adenocarcinoma pathogenesis

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NSD2 amplifies oncogenic transcriptional output to promote lung adenocarcinoma pathogenesis [RNA-seq]

Project description:NSD2 amplifies oncogenic transcriptional output to promote lung adenocarcinoma pathogenesis [RNA-seq]

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NSD2 amplifies oncogenic transcriptional output to promote lung adenocarcinoma pathogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

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GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

Project description:Genomic amplification of the androgen receptor (AR) is an established mechanism of antiandrogen resistance in prostate cancer. Here we show that the magnitude of AR signaling output, independent of AR genomic alteration or expression level, also contributes to antiandrogen resistance, through upregulation of the coactivator GREB1. We demonstrate 100-fold heterogeneity in AR output within cell lines and show that cells with high AR output have reduced sensitivity to enzalutamide. Through transcriptomic and shRNA knockdown studies, together with analysis of clinical datasets, we identify GREB1 as a gene responsible for high AR output. We show that GREB1 is an AR target gene that amplifies AR output by enhancing AR DNA binding and promoting p300 recruitment. GREB1 knockdown in high AR output cells restores enzalutamide sensitivity in vivo. Thus, GREB1 is a candidate driver of enzalutamide resistance through a novel feed forward mechanism.

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GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

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Genome-wide identification of transcriptional targets for PSMD14 and NSD2 in LP-1 cells

Project description:To investigate the genome-wide transcription targets of PSMD14-NSD2 complex and to explore the gain-of-function of PSMD14-NSD2 complex in multiple myeloma, cleavage under targets and tagmentation (CUT&Tag) was performed in LP-1 cells using antibodies against PSMD14 or NSD2. Following CUT&Tag, DNAs were amplified using non-biased conditions, labeled, and sequenced with Illumina NovaSeq 150PE.

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GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

Project description:GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

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GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

Project description:GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

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