Project description:Dietary lipids can affect metabolic health through gut microbiota-mediated mechanisms, but the influence of lipid-microbiota interaction on liver steatosis is unknown. We investigated the effect of dietary lipid composition on human microbiota in an observational study and combined diet experiments with microbiota transplants to study lipid-microbiota interactions and liver status in mice. In humans, low intake of saturated fatty acids (SFA) was associated with increased microbial diversity independent of fiber intake. In mice, cecum levels of SFA correlated negatively with microbial diversity and were associated with a shift in butyrate and propionate producers. Mice fed poorly absorbed SFA had improved metabolism and liver status. These features were transmitted by microbial transfer. Diets enriched in n-6- and/or n-3-polyunsaturated fatty acids were protective against steatosis but had minor influence on the microbiota. In summary, we find that unabsorbed SFA correlate with microbiota features that may be targeted to decrease liver steatosis.
Project description:To compare the changes in the gut microbial composition in the cecum of mice following the 4 treatments (IFvsAL with(out) vancomycin co-treatment)
2022-04-12 | GSE162763 | GEO
Project description:Microbial diversity in GK rats cecum
| PRJNA830524 | ENA
Project description:microbial community diversity of duck gut
| PRJNA787257 | ENA
Project description:Microbial community diversity of Linwu duck
| PRJNA723283 | ENA
Project description:Study of microbial diversity in mice cecum
Project description:To understand the diversity of IELs in the gastrointestinal tract, CD45.2+ IELs from stomach, small intestine, cecum and colon of C57BL/6 mice were isolated for single cell RNA sequencing.
