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Human cortical organoids with engineered microglia-like cells [scRNA-Seq] Apr 05, 2024 pending None

ABSTRACT: Human cortical organoids with engineered microglia-like cells [scRNA-Seq] Apr 05, 2024 pending None

PROVIDER: PRJNA733337 | ENA |

REPOSITORIES: ENA

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Human cortical organoids with engineered microglia-like cells [scRNA-Seq] Apr 05, 2024 pending None

Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:p53 mutation is common and highly related to radiotherapy resistance in rectal cancer. APR-246, as a small molecule, can restore the tumor-suppressor function to mutant p53. There is no study on combining APR-246 with radiation in rectal cancer; therefore, we examined whether APR-246 sensitized colorectal cancer cells with different p53 status to radiation. The combination treatment had synergistic effects on HCT116p53-R248W/-(p53Mut) cells, followed by HCT116p53+/+(p53WT) cells, and exhibited an additive effect on HCT116p53-/-(p53Null) cells through inhibiting proliferation, enhancing reactive oxygen species, and apoptosis. The results were confirmed in zebrafish xenografts. Comparison of the transcriptome in colorectal cancer cells with different p53 status 72hrs post-treatment with APR-246, irradiation, or the combination of APR-246 with irradiation was carried out. p53Mut and p53WT cells shared more activated pathways and differentially expressed genes following the combination treatment, compared to p53Null cells, although the combination treatment regulated individual pathways in the different cell lines. APR-246 mediated radio-sensitization effects through p53-dependent and -independent ways.

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Transcriptomic analysis of SKM1 cells treated with APR-246 (APR), 5-Azacytidine (AZA) or both (APR-AZA)

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dRNA-seq data of the Streptomyces venezualae WT and mutant (sven6563::apr (rsrR::apr)) strains at time point 16 h

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GEO accession GSE194197 is currently private and is scheduled to be released on Apr 16, 2024.

Project description:GEO accession GSE194197 is currently private and is scheduled to be released on Apr 16, 2024.

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Project description:GEO accession GSE201410 is currently private and is scheduled to be released on Apr 25, 2024.

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GEO accession GSE136578 is currently private and is scheduled to be released on Apr 07, 2024.

Project description:GEO accession GSE136578 is currently private and is scheduled to be released on Apr 07, 2024.

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Ovarian cancers with low CIP2A tumor expression constitute an APR-246 sensitive disease subtype

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Project description:GEO accession GSE168006 is currently private and is scheduled to be released on Mar 05, 2024.

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