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FOS Guards Quiescence and Potency in Human Hematopoietic Stem Cells [CUT&Tag]

ABSTRACT: FOS Guards Quiescence and Potency in Human Hematopoietic Stem Cells [CUT&Tag]

PROVIDER: PRJNA735760 | ENA |

REPOSITORIES: ENA

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FOS Guards Quiescence and Potency in Human Hematopoietic Stem Cells [CUT&Tag]

Project description:Quiescence and limited dividing are critical in preserving potency of hematopoietic stem/progenitor cell (HSPCs) during lifetime, but little is known about how this process is regulated. Here, we show that the mobilized human HSPCs in peripheral blood (PB) are predominantly in a quiescent state, but rapidly exit quiescence and reduce repopulating potency in short-term culture. Through single cell RNA-seq, we identified a panel of regulators highly associated with HSC quiescence exit and cell-cycle entry. These regulators involve different biological processes such as cell-cycle, signaling pathways, metabolisms, etc. Among them, the oncogene, FOS restrains cell-cycle entry and supports repopulating potency in human HSCs through directly binding and regulating genes both for HSC quiescence and potency. Our findings uncover the regulatory program underlying quiescence exit and highlight the critical role of FOS to guard the quiescence and potency in human HSPCs.

2021-06-08 | GSE176316 | GEO

FOS Guards Quiescence and Potency in Human Hematopoietic Stem Cells

Project description:FOS Guards Quiescence and Potency in Human Hematopoietic Stem Cells

| PRJNA735759 | ENA

FOS Guards Quiescence and Potency in Human Hematopoietic Stem Cells [scRNA-seq]

2021-06-08 | GSE176272 | GEO

FOS Guards Quiescence and Potency in Human Hematopoietic Stem Cells [RNA-seq]

2021-06-08 | GSE176317 | GEO

FOS Guards Quiescence and Potency in Human Hematopoietic Stem Cells [RNA-seq]

Project description:FOS Guards Quiescence and Potency in Human Hematopoietic Stem Cells [RNA-seq]

| PRJNA735761 | ENA

FOS Guards Quiescence and Potency in Human Hematopoietic Stem Cells [scRNA-seq]

Project description:FOS Guards Quiescence and Potency in Human Hematopoietic Stem Cells [scRNA-seq]

| PRJNA735710 | ENA

FOS Guards Quiescence and Potency in Human Hematopoietic Stem Cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-08 | GSE176318 | GEO

Transcription profiling of brains from honey bees guards of different subspecies and host colony environment

Project description:Expression profiling of guards brains as a function of individual genotype (AHB/EHB) and environment (AHB/EHB host colony)

2009-07-01 | E-TABM-606 | biostudies-arrayexpress

CUT&Tag of oxygen-induced retinopathy mouse retina

Project description:c-Fos and c-Jun form activator protein 1 (AP-1) transcription factors that regulate gene expression by binding to specific motifs on the genome. To investigate c-Fos regulating genes in OIR rod photoreceptor cells, we performed CUT&Tag subjecting normoxia P14 and OIR P14 retina using c-Fos, H3K27ac (enhancer maker), H3K4me3 (active promoter maker), and H3K27me3 ( gene repression maker) antibodies.

2024-03-14 | GSE245456 | GEO

Tubastatin A maintains skeletal muscle stem cell (MuSC) quiescence

Project description:We show that Tubastatin A (TubA) preserves MuSC quiescence and stem cell potency ex vivo, by inhibiting HDAC6 and, consequently, primary cilium resorption. Treatment with TubA improves MuSC engraftment potential and induces a return to quiescence in cycling MuSCs, revealing a potentially valuable approach to enhancing the therapeutic potential of MuSCs. To examine the state of quiescence preserved by TubA at the transcriptome level, we performed RNA-Seq and we found that TubA-treated MuSCs exhibit a quiescent transcriptome. The molecular mechanisms involved in the maintenance of quiescence by TubA were ribosome- and oxidative phosphorylation-related genes as well as low expression levels of cell cycle genes and Hh signaling genes.

2022-01-28 | GSE178070 | GEO

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