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Co-ordinated humoral and cell-mediated immune responses drive class-switched antibody production and improved patient survival in endometrial cancer

ABSTRACT: Co-ordinated humoral and cell-mediated immune responses drive class-switched antibody production and improved patient survival in endometrial cancer

PROVIDER: PRJNA748350 | ENA |

REPOSITORIES: ENA

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Co-ordinated humoral and cell-mediated immune responses drive class-switched antibody production and improved patient survival in endometrial cancer

Project description:NOT PROVIDED; REQUESTED

2022-01-20 | GSE180455 | GEO

BCR repertoire analyis of class-switched and non-switched thymic B cells

Project description:We report that a large percentage of thymic B cells undergo class switching intrathymically. Thymic B cell class switching requires cognate T-B interaction. To determine whether B cell specificity was also important for thymic B cell class-switching, we sorted class-switched thymic B cells (CD19+B220+IgM-IgD-), unswitched B cells (CD19+B220+IgM+IgD+) and bulk splenic B cells in 3H9 heavy chain-fixed mice and performed high throughput sequencing analysis of the light chain of these populations. Results of this analysis indicated that class-switched thymic B cells have a distinct repertoire compared with unswitched thymic B cells and splenic B cells. Further reactivity tests indicated that a large part of BCRs enriched in class-switched thymic B cells are autoreactive. These data suggest that autoreactive B cells are selected into class-switched population and expanded in the thymus.

2016-08-10 | GSE85366 | GEO

BCR repertoire analyis of class-switched and non-switched thymic B cells

2016-08-10 | E-GEOD-85366 | biostudies-arrayexpress

Gene expression profiling of human Ig class switched memory B cells

Project description:We purified 4 Ig class switched memory B cell populations from human adults to compare their gene expression profiles with each other and with those of human naive and IgM memory B cells generated in a previous experiment (E-MEXP-3767).

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Project description:This study used RNAseq to study the mechanism of cellular and humoral rejection by comparing clinical samples of cellular, humoral, mixed, and normal.

2018-10-16 | GSE74261 | GEO

Synthetically mannosylated antigens induce antigen-specific humoral tolerance and prevent anti-drug antibody responses to immunogenic biologics

Project description:The purpose of this study were to test the feasibility of using pMan-antigen therapy to induce humoral tolerance. We used OVA as a model protein along with TCR transgenic OT-I and OT-II to study antigen-specific CD4+ T cell phenotypes and transcriptomic responses using RNA-seq readouts.

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Metabolic control of Tfh and humoral immunity by phosphatidylethanolamine

Project description:Cytidine diphosphate (CDP)-ethanolamine pathway of phospholipid metabolism coordinates metabolic programming of Tfh cell responses and humoral immunity.

2021-05-26 | GSE147190 | GEO

Transcriptional profiling of germinal center B cells and isotype switched memory B cells (scRNA-Seq)

Project description:Germinal center B cells were analyzed for memroy B cell gene signature to identify a memory B cell precursor population. Sorted isotype-switched memory B cells were used to confirm the identified memroy B cell precursor population

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Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination

Project description:Whole blood transcriptomics analysis of healthy individuals, immunized with the trivalent 2012-2013 season flu vaccine via transcutaneous, intramuscular or intradermal route. We define an early gene expression profile, detected at day 1 after immunization, that is associated with the development of either humoral or cytotoxic CD8 T cell responses. We used System Biology approach to analyse vaccine efficacy in order to find innate predictive biomarkers of the quality of adaptive responses for potential clinical use in the future. Moreover, from a methodological point of view this study increases knowledges on how vaccine route(s) can affect resulting immune responses and into mechanisms involved in the induction of humoral and cellular immunity to influenza vaccination.

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2024-03-04 | GSE254265 | GEO

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