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MEOX2 homeobox gene promotes growth of malignant gliomas [RNA-Seq]

ABSTRACT: MEOX2 homeobox gene promotes growth of malignant gliomas [RNA-Seq]

PROVIDER: PRJNA750790 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15300634.fastq.gz	Fastqsanger.gz
	SRR15300635.fastq.gz	Fastqsanger.gz
	SRR15300636.fastq.gz	Fastqsanger.gz
	SRR15300637.fastq.gz	Fastqsanger.gz
	SRR15300638.fastq.gz	Fastqsanger.gz

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MEOX2 homeobox gene promotes growth of malignant gliomas

Project description:MEOX2 homeobox gene promotes growth of malignant gliomas

| PRJNA750780 | ENA

MEOX2 homeobox gene promotes growth of malignant gliomas [RNA-Seq]

Project description:Glioblastoma (GBM) is an aggressive tumor that frequently exhibits gain of chromosome 7, loss of chromosome 10 and aberrantly activated RTK signaling pathways. Here, we identify mesenchymal homeobox 2 (MEOX2) as a salient oncogenic transcription factor candidate with increased expression in GBMs. Our results suggest that MEOX2 can enhance ERK signaling through a feed-forward mechanism. We show that MEOX2 overexpression can lead to increased growth in bona fide GBM implantation models and cooperates with loss of p53 and PTEN in cerebral organoid models of human malignant gliomas to induce cell proliferation. Furthermore, using high-throughput genomics, we identify transcriptional target genes of MEOX2 in patient-derived GBM tumorsphere models and a fresh frozen GBM tumor.

2022-07-01 | GSE181144 | GEO

MEOX2 homeobox gene promotes growth of malignant gliomas [ACT-Seq & CUT&TAG]

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MEOX2 homeobox gene promotes growth of malignant gliomas [ACT-Seq & CUT&TAG]

Project description:MEOX2 homeobox gene promotes growth of malignant gliomas [ACT-Seq & CUT&TAG]

| PRJNA750789 | ENA

MEOX2 homeobox gene promotes growth of malignant gliomas

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-07-01 | GSE181146 | GEO

MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma.

Project description:Nuclear transcription factor Mesenchyme Homeobox 2 (MEOX2) is a homeobox gene that is originally discovered to suppress the growth of vascular smooth muscle and endothelial cells. However, whether or not it is connected to cancer is yet unknown. Here, we report that MEOX2 functions as a tumor-initiating element in glioma. Bioinformatic analyses of public databases and investigation of MEOX2 expression in patients with glioma demonstrated that MEOX2 was abundant at both mRNA and protein levels in glioma. MEOX2 expression was shown to be inversely linked with the prognosis of glioma patients. MEOX2 inhibition changed the morphology of glioma cells, inhibited cell proliferation and motility, whereas had no effect on cell apoptosis. Besides, silencing of MEOX2 also hampered the epithelial-mesenchymal transition (EMT), focal adhesion maturation, and F-actin assembly. Overexpression of MEOX2 exhibited opposite effects. Importantly, RNA-seq, ChIP assay, and luciferase reporter assay revealed Cathepsin S (CTSS) as a novel transcriptional target of MEOX2 in glioma cells. Consistently, MEOX2 causes glioma tumor development in mice and greatly lowers the survival period of tumor-bearing mice. Our findings indicate that MEOX2 promotes tumorigenesis and progression of glioma partially through the regulation of CTSS. Targeting the MEOX2-CTSS axis might be a promising alternative for the treatment of glioma.

2022-04-01 | GSE197758 | GEO

GNPS - Metabolic detection of malignant brain gliomas through lipidomic analysis

Project description:Lipidomic analysis of malignant brain gliomas to search for biomarkers.

2020-07-05 | MSV000085693 | GNPS

Enterovirus 71 oncolysis of malignant gliomas

Project description:This study finds that EV71 has oncolytic activity against experimental human malignant gliomas. RNA-seq analysis of infected glioma cells reveals transcriptional up-regulation, notably genes in apoptosis pathways. Application of virus targeting based on brain-specific microRNA-124 enhances the safety profile. Oncolysis with EV71 may be a potentially novel treatment for malignant gliomas.

2019-08-27 | GSE136330 | GEO

Enterovirus 71 oncolysis of malignant gliomas

Project description:Enterovirus 71 oncolysis of malignant gliomas

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Gene expression data from malignant gliomas

Project description:Formalin-fixed, paraffin-embedded (FFPE) samples of varying grade (II-IV) malignant gliomas were measured by Illumina cDNA-mediated Annealing, Selection, extension and ligration (DASL) platform. DASL platform was selected for its specialized design for partially degraded RNA. Overall mRNA was extracted from FFPE samples using the GoldenGate Assay protocol and hybridized to Illumina BeadChips.

2014-02-13 | E-GEOD-54004 | biostudies-arrayexpress

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