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The DREAM complex antagonizes WDR5a and represses the productive elongation of transcription in Arabidopsis [GRO-seq]

ABSTRACT: The DREAM complex antagonizes WDR5a and represses the productive elongation of transcription in Arabidopsis [GRO-seq]

PROVIDER: PRJNA752163 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15347140_1.fastq.gz	Fastqsanger.gz
	SRR15347140_2.fastq.gz	Fastqsanger.gz
	SRR15347141_1.fastq.gz	Fastqsanger.gz
	SRR15347141_2.fastq.gz	Fastqsanger.gz
	SRR15347142_1.fastq.gz	Fastqsanger.gz

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The DREAM complex antagonizes WDR5a and represses the productive elongation of transcription in Arabidopsis [GRO-seq]

Project description:The master transcriptional repressor DREAM (dimerization partner, RB-like, E2F and multi-vulval class B) complex regulates cell cycle in eukaryotes, but much remains unknown about how it transmits repressive signals on chromatin to the primary transcriptional machinery (e.g., Pol II). Through a genetic screen, we identified BTE1 (barrier of transcription elongation 1), a key component in the plant DREAM complex. The subsequent characterization demonstrated that the DREAM complex represses Pol II elongation. The core DREAM subunits E2F transcription factors recruit BTE1 to accumulate at the promoter-proximal regions of target genes. DREAM target genes exhibit characteristic enrichment of H2A.Z and H3K4me2 modification on chromatin. The DREAM complex BTE1 subunit interacts with WDR5a, repressing WDR5a chromatin binding and the productive elongation of transcription on BTE1-targeted genomic loci. Thus, we demonstrate a major role of DREAM complex in the control of transition from transcription initiation to productive elongation around TSSs on the open chromatin via inhibiting WDR5a function.

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The DREAM complex antagonizes WDR5a and represses the productive elongation of transcription in Arabidopsis [ChIP-seq]

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The DREAM complex antagonizes WDR5a and represses the productive elongation of transcription in Arabidopsis

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Project description:The DREAM complex antagonizes WDR5a and represses the productive elongation of transcription in Arabidopsis [ChIP-seq]

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The DREAM complex antagonizes WDR5a and represses the productive elongation of transcription in Arabidopsis

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Project description:The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle and other genes, but its mechanism of action is unclear. Here we demonstrate that two C. elegans THAP domain proteins, LIN-15B and LIN-36, co-localize with DREAM and function by different mechanisms for repression of distinct sets of targets. LIN-36 represses classical cell cycle targets by promoting DREAM binding and gene body enrichment of H2A.Z. Furthermore, the function of DREAM subunit EFL-1/E2F is specific for LIN-36 targets. In contrast, LIN-15B represses a subset of germline targets by facilitating H3K9me2 promoter marking. In humans, THAP proteins have been implicated in cell cycle regulation by poorly understood mechanisms. We propose that THAP domain proteins are key mediators of Rb/DREAM function, facilitating repression of distinct sets of targets.

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