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Buddleja alternifolia

ABSTRACT: Buddleja alternifolia overview

PROVIDER: PRJNA755391 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	WHWC01.dat.gz	Other
	WHWC01.fasta.gz	Fasta.gz
	WHWC01.master.dat	Other
	SRR10305100_1.fastq.gz	Fastqsanger.gz

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Project description:Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptors superfamily and are transcription factors activated by specific ligands. Liver X receptors (LXR) belong to the nuclear hormone receptors and have been shown to play an important role in cholesterol homeostasis. From the previous screening of several medicinal plants for potential partial PPAR? agonists, the extracts of Cornus alternifolia were found to exhibit promising bioactivity. In this paper, we report the isolation and structural elucidation of four new compounds and their potential as ligands for PPAR.The new compounds were extracted from the leaves of C. alternifolia and fractionated by high-performance liquid chromatography. Their structures were elucidated on the basis of spectroscopic evidence and analysis of their hydrolysis products.Three new iridoid glycosides including an iridolactone, alternosides A-C (1-3), a new megastigmane glycoside, cornalternoside (4) and 10 known compounds, were obtained from the leaves of C. alternifolia. Kaempferol-3-O-?-glucopyranoside (5) exhibited potent agonistic activities for PPAR?, PPAR? and LXR with EC50 values of 0.62, 3.0 and 1.8 ?M, respectively.We isolated four new and ten known compounds from C. alternifolia, and one known compound showed agonistic activities for PPAR?, PPAR? and LXR.Compound 1 is the first example of a naturally occurring iridoid glycoside containing a ?-glucopyranoside moiety at C-6.

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Characterization of the complete chloroplast genome of <i>Buddleja alternifolia</i> (Buddleiaceae).

Project description:The complete chloroplast genome sequence of Buddleja alternifolia, a perennial garden plant and common medicinal plant is widely distributed in west China. The plastome is 154,357 bp in length, with one large single copy region of 85,406 bp, one small single copy region of 18,071 bp, and two inverted repeat (IR) regions of 25,440 bp. It contains 130 genes, including 85 protein-coding genes, 8 ribosomal RNA, and 37 transfer RNA. Phylogenetic tree shows that B. alternifolia formed one clade with Buddleja colvilei and Buddleja sessilifolia. The published plastome of B. alternifolia provides significant insight for elucidating the phylogenetic relationship of taxa genus Buddleja.

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Melaleuca alternifolia concentrate inhibits in vitro entry of influenza virus into host cells.

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