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Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β-cell function

ABSTRACT: Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β-cell function

PROVIDER: PRJNA758382 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15654701_1.fastq.gz	Fastqsanger.gz
	SRR15654701_2.fastq.gz	Fastqsanger.gz
	SRR15654702_1.fastq.gz	Fastqsanger.gz
	SRR15654702_2.fastq.gz	Fastqsanger.gz
	SRR15654703_1.fastq.gz	Fastqsanger.gz

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Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β-cell function [scATAC-seq]

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Project description:Circadian rhythm disruption (CD) is associated with dysregulation of glucose homeostasis and Type 2 diabetes mellitus (T2DM). While the link between CD and T2DM remains unclear, there is accumulating evidence that disruption of fasting/feeding cycles mediates CD-induced metabolic dysfunction. Herein we utilized an approach encompassing analysis of behavioral, physiological, transcriptomic, and single-cell epigenomic effects of CD and consequences of restoration of fasting/feeding cycles through time-restricted feeding (tRF) in mice. Results show that CD perturbs glucose homeostasis through disruption of pancreatic β-cell function and loss of circadian β-cell transcriptional and epigenetic control. In contrast, restoration of fasting/feeding cycle prevented CD-mediated metabolic dysfunction by reestablishing circadian regulation of glucose tolerance, β-cell function, β-cell transcriptional profile, and reestablishment of proline and acidic amino acid-rich basic leucine zipper (PAR-bZIP) transcription factor activity in β-cells. This study provides mechanistic insights into beneficial effects of tRF and its role in prevention of β-cell failure in T2DM.

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