Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell analysis of experimental autoimmune orchitis (EAO) in mice

ABSTRACT: single-cell analysis of experimental autoimmune orchitis (EAO) in mice

PROVIDER: PRJNA761421 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Quantitative proteomic analysis of experimental autoimmune encephalomyelitis mice implicates SUMOylation in multiple sclerosis

Project description:In this study, we performed quantitative proteomics utilizing a data-independent acquisition (DIA) strategy to investigate the proteome alteration in the brain and spinal cord tissues from mice with experimental autoimmune encephalomyelitis (EAE), a widely-used model for MS.

2024-03-20 | PXD050789 | iProX

Effect of Compound Edaravone on Experimental Autoimmune Encephalitis Mice Lumbar Spinal Cord

Project description:Researchers have induced an experimental model of multiple sclerosis [experimental autoimmune encephalomyelitis (EAE)] in C57BL/6 mice to test the neuro-therapeutic effect of Compound Edaravone (CEDA, Jiangsu Simcere Pharmaceutical Co., Ltd., Nanjing, China) during the disease peak and investigate its possible mechanisms

2022-12-31 | GSE186318 | GEO

lncRNA and mRNA expression signatures for experimental autoimmune encephalomyelitis model mice and normal mice

Project description:To explore the potential roles of lncRNAs in the progress of multiple sclerosis, spleens of experimental autoimmune encephalomyelitis (EAE) model mice and normal mice were used as the samples to obtain the expression profiles of lncRNAs and mRNAs with the mouse LncRNA Array v3.0.

2020-06-04 | GSE151701 | GEO

Single cell analysis of CD45-positive immune cells infiltrating the central nervous system of mice undergoing experimental autoimmune encephalomyelitis.

Project description:Single cell analysis of CD45-positive immune cells infiltrating the central nervous system of mice undergoing experimental autoimmune encephalomyelitis.

| PRJEB49944 | ENA

lncRNA and mRNA expression signatures for experimental autoimmune encephalomyelitis model mice and normal mice

Project description:lncRNA and mRNA expression signatures for experimental autoimmune encephalomyelitis model mice and normal mice

| PRJNA636987 | ENA

Dysfunction of retinal dopaminergic system exacerbates experimental autoimmune uveoretinitis in Gnat1rd17 mice

Project description:This study investigated the effect of the Gnat1 (rod transducin alpha subunit) gene deficiency in Gnat1rd17 mice on the retinal transcriptome remodeling, and whether this remodeling is protective or maladaptive with regard to photoreceptor damage driven by autoimmune process. The results of this study showed that Gnat1rd17 mice exhibited transcriptomic changes indicative of remodeling in photoreceptor segments and connecting cilium, deregulated inflammatory pathways and dopaminergic signaling, followed by development of exacerbated experimental autoimmune uveoretinitis, which was ameliorated by dopamine replacement. These findings suggest rod transducin alpha subunit a critical modulator of retinal homeostasis and immune response through regulation of retinal dopaminergic system.

2022-01-11 | E-MTAB-10863 | biostudies-arrayexpress

Single-cell transcriptomic analysis of retinal immune regulation and blood-retinal barrier function during experimental autoimmune uveitis

Project description:Uveitis is characterised by breakdown of the blood-retinal barrier (BRB), allowing infiltration of immune cells that mediate intraocular inflammation, which can lead to irreversible damage of the neuroretina and the loss of sight. Treatment of uveitis relies heavily on corticosteroids and systemic immunosuppression due to limited understanding of the molecular immune interactions that underpin ocular immune homeostasis. By performing single-cell transcriptomic analysis of whole dissociated mouse retinas with experimental autoimmune uveitis (EAU) versus healthy control, we gained an unbiased appreciation of the immune interactions that drive retinal inflammation in a model of posterior uveitis.

2024-08-29 | GSE241700 | GEO

Differential expression of genes in spinal cord folowing experimental autoimmune encephalomyelitis (EAE) in mice.

Project description:Microarrays were used to identify genes that were differently expressed in mouse spinal cord as a resut of experimental autoimmune encephalomyelitis (EAE), which is a model for demyelinating disease. Mice were injected with PLP peptide or vechicle.

2013-08-01 | E-GEOD-44989 | biostudies-arrayexpress

CLIPseq of hnRNP A1 from the spinal cords of mice with experimental autoimmune encephalomyelitis

Project description:Experimental autoimmune encephalomyelitis (EAE) is a mouse model for multiple sclerosis (MS) a chronic autoimmune disease of the central nervous system. We have observed dysfunction of the RNA binding protein hnRNP A1 in neurons from the brains of patients with MS, and the spinal cords of mice with EAE. Here, we sought to characterize the consequences of EAE-induced dysfunction of hnRNP A1 on the RNAs it binds by using CLIPseq to establish both the normal central nervous system RNA binding profile of hnRNP A1 in the spinal cords of naive mice, and any alterations to the binding profile of hnRNP A1 in the spinal cords of mice with EAE.

2024-01-04 | GSE208093 | GEO

Murine CD4+ T cells: naive vs. experimental autoimmune uveitis

Project description:miRNA expression profiling of CD4+ T cells comparing naïve mice and experimental autoimmune uveitis (EAU) mice. EAU was induced by immunization of retinal antigen (IRBP1-20) in complete Freund’s adjuvant (CFA). CD4+ T cells were isolated and purified from the spleen and draining lymph nodes 13 days after immunization.

2022-09-10 | GSE213034 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data