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FAM72A promotes mutagenic repair during antibody maturation

ABSTRACT: FAM72A promotes mutagenic repair during antibody maturation

PROVIDER: PRJNA761718 | ENA |

REPOSITORIES: ENA

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FAM72A promotes mutagenic repair during antibody maturation

Project description:Genome-wide CRISPR screen in murine CH12F3-2 cell line to identify novel factors involved in antibody class switch recombination. FAM72A, a protein with no ascribed function, was identified in this screen as a major determinant during mutagenic uracil repair by antagonizing base excision repair protein UNG2.

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The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKK kinases prior to complex assembly

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PI3Kg in B cells promotes antibody responses and generation of antibody-secreting cells [scRNA-seq]

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