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Mechanisms of Sinoatrial Node Dysfunction in Heart Failure with Preserved Ejection Fraction

ABSTRACT: Mechanisms of Sinoatrial Node Dysfunction in Heart Failure with Preserved Ejection Fraction

PROVIDER: PRJNA763219 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15898324.fastq.gz	Fastqsanger.gz
	SRR15898325.fastq.gz	Fastqsanger.gz
	SRR15898326.fastq.gz	Fastqsanger.gz
	SRR15898327.fastq.gz	Fastqsanger.gz
	SRR15898328.fastq.gz	Fastqsanger.gz

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Mechanisms of Sinoatrial Node Dysfunction in Heart Failure with Preserved Ejection Fraction

Project description:RNA sequencing from sinoatrial node tissue was performed to identify transcriptomic changes in Dahl salt-sensitive rats fed with normal salt diet (0.4% NaCl, control group) or high-salt diet (8% NaCl, HFpEF group) for 11 weeks. Transcriptomic profiling revealed numerous changes in multiple disease-associated genes in HFpEF, which is functionally related to the observed physiological impairments and structural remodeling.

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Circulating microRNAs are candidate markers of heart failure and differentiate between heart failure with reduced vs preserved left ventricular ejection fraction.

Project description:In this study, we compared the expression profiles of circulating miRNAs in blood samples from controls and patients with heart ailment. Subject with no past history of heart failure/disease are considered as controls. The patients were classified according to the percentage of left ventricular ejection fraction. Patients were grouped as heart failure with reduced (hfREF) and preserved (hfPEF) left ventricular ejection fraction. Employing miRNA microarray, we identified 'signature miRNAs' in peripheral blood samples that distinguished Heart failure from the non-heart failure controls, as well as those of hfREF and hfPEF groups.

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Project description:Recent studies have suggested that epicardial adipose tissue (EAT) play an important role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF), but few have characterized the underlying mechanism between their interactions. Recent evidence suggested that molecules secreted from EAT, including exosomes carrying non-coding RNAs (ncRNAs), may participate in the development of HFpEF. The aim of the present study was to investigate the expression profile of mRNAs and ncRNAs in EAT with HFpEF.

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