Ontology highlight
ABSTRACT:
PROVIDER: PRJNA772164 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Myanmar locates in the crossroads of South Asia, Southeast Asia, and East Asia, and is known for high culture diversity in different ethnic groups. It is considered to be important for understanding human evolutionary history and genetic diversity in East Eurasia. However, relatively few studies have examined the population structure and demographic history in Myanmar to date. In this study, we analyzed more than 220,000 genome-wide SNPs in 175 new samples of five ethnic groups from Myanmar and compared them with the published data. Our results showed that the Myanmar population is intricately substructured, with the main observed clusters corresponding roughly to western/northern highlanders (Chin, Naga, and Jingpo) and central/southern lowlanders (Bamar and Rakhine). The gene flow inferred from South Asia has a substantial influence (~11%) on the gene pool of central/southern lowlanders rather than western/northern highlanders. The genetic admixture is dated around 650 years ago. These findings suggest that the genome-wide variation in Myanmar was likely shaped by the linguistic, cultural, and historical changes.
2019-12-31 | GSE74100 | GEO
Project description:The species-specific identification of fibre origin is essential in archaeology but reveals challenging for closely related species. This is particularly true between the four South American Camelids (SAC) species: alpaca, guanaco, llama and vicuña. The analysis of proteins extracted from hairs and/or yarns by proteomics has emerged as a powerful method to differentiate between species. However, for SAC, the database information available is very poor, which limits this approach. In this study, we analysed 42 modern and 4 archaeological reference samples from the four SAC species.
2020-11-09 | PXD018980 | Pride
Project description:Boreal toads (Anaxyrus boreas boreas) of the Southern Rocky Mountain population are declining due to the introduction of the chytrid fungus Batrachochytrium dendrobatidis (Bd). Boreal toads in Colorado are generally susceptible to Bd infection, but some Bd-tolerant populations persist in parts of the Southern Rocky Mountain and broader Eastern boreal toad population. We conducted a Bd challenge with lab-reared sibling toads from Bd-susceptible Colorado and purportedly Bd-tolerant Utah populations and report on transcriptomic responses to Bd during late infection in skin and liver tissue. Fewer immune genes were expressed in response to Bd in Colorado toads, but with greater upregulation compared to Utah toads, indicating a dysregulated immune response. Signatures of Bd-tolerance in Utah toads included more moderate upregulation in immune gene expression and a significantly enriched suite of gene functions related to innate and adaptive immune responses. Our transcriptomic results support the notion that Utah toads are tolerant to Bd, rather than resistant, carrying Bd loads similar to Colorado yet having a unique transcriptomic profile and presenting minimal clinical signs of chytridiomycosis. We conclude that closely related populations have divergent transcriptomic responses to Bd with a dysregulated immune response in Bd-susceptible toads.
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Project description:Proteomics characterization of the venoms of the two subspecies (bilineatus and smaragdinus) of the poorly studied South American palm pitviper Bothrops bilineatus from the Brazilian state of Rondônia
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Project description:Proteomics characterization of the venoms of the two subspecies (bilineatus and smaragdinus) of the poorly studied South American palm pitviper Bothrops bilineatus from the Brazilian state of Rondônia
2020-08-20 | PXD020026 | Pride