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Wild-type, Foxa2-/-, and Nkx2.2-/- mESCs at different time points of differentiation

ABSTRACT: Wild-type, Foxa2-/-, and Nkx2.2-/- mESCs at different time points of differentiation

PROVIDER: PRJNA784960 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17075131.fastq.gz	Fastqsanger.gz
	SRR17075132.fastq.gz	Fastqsanger.gz
	SRR17075133.fastq.gz	Fastqsanger.gz
	SRR17075134.fastq.gz	Fastqsanger.gz
	SRR17075135.fastq.gz	Fastqsanger.gz

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Wild-type, Foxa2-/-, and Nkx2.2-/- mESCs at different time points of differentiation

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Project description:The goal of this experiment was to analyze expression changes in the pancreas at embryonic days 12.5 and 13.5 between wild type and Nkx2.2 null mice. We know that Nkx2.2 is essential for pancreatic endocrine differentiation and development. At these early time points which are critical for endocrine cell specification, we would like to identify a transcriptional program that Nkx2.2 regulates. We would also like to identify direct and functional transcriptional targets of Nkx2.2.

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