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A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis [RMRP_SHAPE]

ABSTRACT: A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis [RMRP_SHAPE]

PROVIDER: PRJNA788472 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17217782_1.fastq.gz	Fastqsanger.gz
	SRR17217782_2.fastq.gz	Fastqsanger.gz
	SRR17217783_1.fastq.gz	Fastqsanger.gz
	SRR17217783_2.fastq.gz	Fastqsanger.gz
	SRR17217784_1.fastq.gz	Fastqsanger.gz

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A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis

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A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis [RMRP_SHAPE]

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A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis

Project description:This SuperSeries is composed of the SubSeries listed below.

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RNAi profiling by array of human HEp-2 cells with siRNA-mediated depletion of RNase MRP protein components

Project description:To identify mRNA substrates for the human RNase MRP complex, we examined the effects of siRNA-mediated depletion of RNase MRP (and RNase P) on the transcriptome of HEp-2 cells. The expression of two RNase MRP protein components, hPop1 and Rpp40, was knocked-down and after 48 hours mRNA was isolated from these cells as well as from cells transfected with an siRNA targeting the GFP mRNA (siEGFP), which was used as a control. The expression levels of mRNAs were analyzed on a genome-wide scale using 21K microarrays.

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