Project description:To explore the potential mechanism through which CMR regulates PANC-1 cells, a transcriptome sequencing analysis was performed to profile the difference between CMR-treated cells and control cells. Two thousand six hundred seventy-two differentially regulated genes were identified, of which 1678 and 1872 were up- and down-regulated, respectively. Subsequently, we conducted a Gene Ontology (GO) analysis of CMR targets. The results indicated that these targets were broadly distributed in the cytoplasm, nucleus, endoplasmic reticulum, and Golgi apparatus. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis predicted that CMR was involved in various signaling pathways, including mammalian target of rapamycin (mTOR), PI3K-AKT, AMPK, MAPK, FoxO, VEGF, WNT, autophagy, apoptosis and so on.
Project description:To identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, hypopharyngeal squamous cell carcinoma and prostate cancer) were subjected to Agilent whole genome microarrays. Human cell lines (Panc-1, FaDu and PC3) were treated with miRNAs (miR99a-5p, miR-99a-3p, miR-100-3p, miR-150-5p and miR-150-3p), siRNAs (si-FOXQ1).
Project description:To identify the differentially expressed gene in ikras cells treated with Trametinib, 2DG and Trametinib/2DG combination. Two ikras cells were used for transcriptomics analysis by RNAseq.