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Helminth-induced reprogramming of the stem cell niche inhibits type 2 immunity [scRNA-seq]

ABSTRACT: Helminth-induced reprogramming of the stem cell niche inhibits type 2 immunity [scRNA-seq]

PROVIDER: PRJNA818987 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18443932.fastq.gz	Fastqsanger.gz
	SRR18443933.fastq.gz	Fastqsanger.gz
	SRR18443934.fastq.gz	Fastqsanger.gz
	SRR18443935.fastq.gz	Fastqsanger.gz

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Helminth-induced reprogramming of the stem cell niche inhibits type 2 immunity

Project description:Helminth-induced reprogramming of the stem cell niche inhibits type 2 immunity

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Helminth-induced reprogramming of the stem cell niche inhibits type 2 immunity [Bulk RNA-seq]

Project description:Helminth-induced reprogramming of the stem cell niche inhibits type 2 immunity [Bulk RNA-seq]

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Helminth-induced reprogramming of the stem cell niche inhibits type 2 immunity [scRNA-seq]

Project description:Enteric helminths form intimate physical connections with the intestinal epithelium, yet their ability to directly alter epithelial stem cell fate has not been resolved. Here we demonstrate that infection of mice with the symbiotic parasite Heligmosomoides polygyrus bakeri (Hpb), reprograms the intestinal epithelium into a fetal-like state marked by the emergence of Clusterin-expressing revival stem cells (revSCs). Organoid-based studies using parasite-derived excretory/secretory products reveal that Hpb-mediated revSC generation occurs independent of host-derived immune signals and inhibits type 2 cytokine-driven differentiation of secretory epithelial lineages that promote their expulsion. Reciprocally, type 2 cytokine signals limit revSC differentiation and, consequently, Hpb fitness indicating that helminths compete with their host for control of the intestinal stem cell niche to promote continuation of their life cycle.

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Helminth-induced reprogramming of the stem cell niche inhibits type 2 immunity [Bulk RNA-seq]

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Hydroxychloroquine inhibits trained immunity

Project description:Hydroxychloroquine inhibits trained immunity

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Hydroxychloroquine inhibits trained immunity

Project description:We demonstrate that hydroxychloroquine inhibits trained immunity at the functional and epigenetic level and is accompanied by reduced expression of interferon-stimulated genes. Trained immunity comprises a functional adaptation induced by epigenetic reprogramming which facilitates the anti-viral innate immune response.

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Helminth-induced reprogramming of the stem cell niche inhibits type 2 immunity

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-07-14 | GSE199227 | GEO

Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation

Project description:Helminth infection leads to lung remodelling. We used single cell ATAC sequencing (scRNA-seq) to analyze the changes in lung cells following exposure to N. brasiliensis at day 28 and day 45 post helminth infection

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Mitochondrial aconitase inhibits immunity via reducing mitochondrial unfolded protein response

Project description:We show that mitochondrial aconitase, ACO-2, a Krebs cycle enzyme that catalyzes the conversion of citrate to isocitrate, inhibits immunity against pathogenic bacteria in C. elegans. We found that genetic inhibition of aco-2 enhanced mitochondrial unfolded protein response, subsequently upregulating ATFS-1 transcription factor, which contributed to enhanced immunity against pathogenic bacteria.

2023-06-01 | GSE181546 | GEO

Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation

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